Genome-wide detection of recurring sites of uniparental disomy in follicular and transformed follicular lymphoma

@article{Fitzgibbon2007GenomewideDO,
  title={Genome-wide detection of recurring sites of uniparental disomy in follicular and transformed follicular lymphoma},
  author={Jude Fitzgibbon and Sameena Iqbal and Andrew Davies and Derville O'Shea and Emanuela Carlotti and Tracy Chaplin and John M. Matthews and Manoj Raghavan and Andrew Norton and T. Andrew Lister and Bryan D. Young},
  journal={Leukemia},
  year={2007},
  volume={21},
  pages={1514-1520}
}
Single-nucleotide polymorphism (SNP) array analysis was performed using the 10K GeneChip array on a series of 26 paired follicular lymphoma (FL) and transformed-FL (t-FL) biopsies and the lymphoma cell lines SCI-1, DoHH2 and RL2261. Regions of acquired homozygosity were detected in 43/52 (83%) primary specimens with a mean of 1.7 and 3.0 aberrations in the FL and t-FL, respectively. A notable feature was the occurrence of recurring sites of acquired uniparental disomy (aUDP) on 6p, 9p, 12q and… CONTINUE READING
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