Genome-wide comparison of two RNA-stabilizing reagents for transcriptional profiling of peripheral blood.

@article{Nikula2013GenomewideCO,
  title={Genome-wide comparison of two RNA-stabilizing reagents for transcriptional profiling of peripheral blood.},
  author={Tuomas Nikula and Juha Mykk{\"a}nen and Olli Simell and Riitta Lahesmaa},
  journal={Translational research : the journal of laboratory and clinical medicine},
  year={2013},
  volume={161 3},
  pages={181-8}
}
Peripheral whole blood is relatively easily obtained for monitoring gene expression for biomarker discovery using transcriptomic platforms such as genome-wide microarrays. However, whole blood provides challenges caused by sensitivity for ex vivo incubation and overrepresentation of globin mRNAs. We compared the performance of 2 commercial whole blood preservation methods, TEMPUS (Applied Biosystems, Foster City, CA) and PAXgene (PreAnalytiX, Qiagen BD, Valencia, CA), using 2 RNA amplification… CONTINUE READING
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