Genome-wide comparison of medieval and modern Mycobacterium leprae.

  title={Genome-wide comparison of medieval and modern Mycobacterium leprae.},
  author={Verena J. Schuenemann and Pushpendra Singh and Thomas A Mendum and Ben Krause-Kyora and G{\"u}nter J{\"a}ger and Kirsten I. Bos and Alexander Herbig and Christos Economou and Andrej Benjak and Philippe Busso and Almut Nebel and Jesper Lier Boldsen and Anna Kjellstr{\"o}m and Huihai Wu and Graham R Stewart and G. Michael Taylor and Peter Bauer and Oona Y-C Lee and Houdini Ho Tin Wu and David E. Minnikin and Gurdyal S Besra and Katie Tucker and Simon Roffey and Samba Ousmane Sow and Stewart T Cole and Kay Nieselt and Johannes Krause},
  volume={341 6142},
Leprosy was endemic in Europe until the Middle Ages. Using DNA array capture, we have obtained genome sequences of Mycobacterium leprae from skeletons of five medieval leprosy cases from the United Kingdom, Sweden, and Denmark. In one case, the DNA was so well preserved that full de novo assembly of the ancient bacterial genome could be achieved through… CONTINUE READING