Genome-wide binding map of the histone deacetylase Rpd3 in yeast

  title={Genome-wide binding map of the histone deacetylase Rpd3 in yeast},
  author={Siavash K Kurdistani and Daniel Robyr and Saeed Tavazoie and Michael R. Grunstein},
  journal={Nature Genetics},
We describe the genome-wide distribution of the histone deacetylase and repressor Rpd3 and its associated proteins Ume1 and Ume6 in Saccharomyces cerevisiae. Using a new cross-linking protocol, we found that Rpd3 binds upstream of many individual genes and upstream of members of gene classes with similar functions in anabolic processes. In addition, Rpd3 is preferentially associated with promoters that direct high transcriptional activity. We also found that Rpd3 was absent from large sub… CONTINUE READING
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