Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

  title={Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity},
  author={Gudmar Thorleifsson and G Bragi Walters and Daniel Fannar Gudbjartsson and Valgerdur Steinthorsdottir and Patrick Sulem and Anna Helgadottir and Unnur Styrkarsdottir and S{\'o}lveig Gr{\'e}tarsd{\'o}ttir and Steinunn Thorlacius and Ingileif J{\'o}nsd{\'o}ttir and Thorbjorg Jonsdottir and El{\'i}nborg J{\'o}na Olafsd{\'o}ttir and Gudridur Helga Olafsd{\'o}ttir and Thorvaldur J{\'o}nsson and Frosti Jonsson and Knut Borch-Johnsen and Torben Hansen and Gitte Andersen and Torben Jorgensen and T Lauritzen and Katja K. H. Aben and Andr{\'e} L. M. Verbeek and Nel Roeleveld and Ellen Kampman and Lisa R Yanek and Lewis C. Becker and Laufey Tryggvadottir and Thorunn Rafnar and Diane M. Becker and Jeffrey Robert Gulcher and Lambertus A. L. M. Kiemeney and Oluf Pedersen and Augustine Kong and Unnur Thorsteinsdottir and K{\'a}ri Stef{\'a}nsson},
  journal={Nature Genetics},
Obesity results from the interaction of genetic and environmental factors. To search for sequence variants that affect variation in two common measures of obesity, weight and body mass index (BMI), both of which are highly heritable, we performed a genome-wide association (GWA) study with 305,846 SNPs typed in 25,344 Icelandic, 2,998 Dutch, 1,890 European Americans and 1,160 African American subjects and combined the results with previously published results from the Diabetes Genetics… CONTINUE READING
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