Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus

  title={Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus},
  author={Timothy R. D. J. Radstake and Olga Y. Gorlova and B. Bryan Rueda and J Martin and Behrooz Z. Alizadeh and Rogelio Jesus Palomino-Morales and Marieke J. H. Coenen and Madelon C. Vonk and Alexandre E. Voskuyl and Annemie J. M. Schuerwegh and Jasper C. A. Broen and Piet L. C. M. van Riel and Ruben van 't Slot and Annet Italiaander and Roel A. Ophoff and Gabriela Riemekasten and Nicolas Hunzelmann and Carmen Pilar Sime{\'o}n and Norb{\'e}rto Ortego-Centeno and Miguel A Gonz{\'a}lez-Gay and Mar{\'i}a-Francisca Gonz{\'a}lez-Escribano and Paolo Air{\'o} and Jaap van Laar and Ariane Herrick and Jane Worthington and Roger Hesselstrand and Vanessa H Smith and Filip De Keyser and Fredric Houssiau and Meng May Chee and Rajan Madhok and Paul G Shiels and Ren{\'e} Westhovens and Alexander Kreuter and Hans P. Kiener and Elfride de Baere and Torsten Witte and Leonid Padykov and Lars Klareskog and Lorenzo Beretta and Rafaella Scorza and Benedicte Alexandra Lie and Anna-Maria Hoffmann-Vold and Patricia Carreira and John Varga and Monique Hinchcliff and Peter K. Gregersen and Annette T. Lee and Jun Ying and Younghun Han and S Weng and Christopher I. Amos and Fredrick Wigley and Laura K. Hummers and J. Lee Nelson and Sandeep K Agarwal and Shervin Assassi and Pravitt Gourh and Filemon K. Tan and Bobby P. C. Koeleman and F. C. Arnett and Javier Mart{\'i}n and Maureen D. Mayes},
  journal={Nature Genetics},
Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin and internal organs that leads to profound disability and premature death. To identify new SSc susceptibility loci, we conducted the first genome-wide association study in a population of European ancestry including a total of 2,296 individuals with SSc and 5,171 controls. Analysis of 279,621 autosomal SNPs followed by replication testing in an independent case-control set of European ancestry (2,753… CONTINUE READING