Genome-wide association study of survival in patients with pancreatic adenocarcinoma.

  title={Genome-wide association study of survival in patients with pancreatic adenocarcinoma.},
  author={Chen Wu and Peter Kraft and Rachael Z. Stolzenberg-Solomon and Emily Steplowski and Michelle J. Brotzman and Mousheng Xu and Poorva Mudgal and Laufey T Amundadottir and Alan A. Arslan and Hendrik Bas Bueno-de-Mesquita and Myron D. Gross and Kathy J. Helzlsouer and Eric J Jacobs and Charles Kooperberg and G. M. van Petersen and Wei Zheng and Demetrius Albanes and Marie-Christine Boutron-Ruault and Julie E. Buring and Frederico Canzian and Guangwen Cao and Eric J Duell and Joanne W. Elena and J. Michael Gaziano and Edward L. Giovannucci and Goran Hallmans and Amy Hutchinson and David J. Hunter and M. Jenab and Guoliang Jiang and Kay-tee Khaw and Andrea Z LaCroix and Zhaoshen Li and Julie Bloch Mendelsohn and Salvatore Panico and Alpa V. Patel and Zhi Rong Qian and Elio Riboli and Howard D Sesso and Hongbing Shen and Xiao-ou Shu and Anne Tjonneland and Geoffrey S. Tobias and Dimitirios Trichopoulos and Jarmo R Virtamo and Kala Visvanathan and Jean Wactawski-Wende and Chengfeng Wang and Kai Yu and Anne Zeleniuch-Jacquotte and Stephen J. Chanock and Robert Nathaniel Hoover and Patricia A Hartge and Charles S. Fuchs and Dongxin Lin and Brian Wolpin},
  volume={63 1},
BACKGROUND AND OBJECTIVE Survival of patients with pancreatic adenocarcinoma is limited and few prognostic factors are known. We conducted a two-stage genome-wide association study (GWAS) to identify germline variants associated with survival in patients with pancreatic adenocarcinoma. METHODS We analysed overall survival in relation to single nucleotide polymorphisms (SNPs) among 1005 patients from two large GWAS datasets, PanScan I and ChinaPC. Cox proportional hazards regression was used… CONTINUE READING
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