Genome-wide association study of prostate cancer identifies a second risk locus at 8q24

@article{Yeager2007GenomewideAS,
  title={Genome-wide association study of prostate cancer identifies a second risk locus at 8q24},
  author={Meredith Yeager and Nick Orr and Richard B Hayes and Kevin Bruce Jacobs and Peter Kraft and Sholom Wacholder and Mark J Minichiello and Paul Fearnhead and Kai Yu and Nilanjan Chatterjee and Zhaoming Wang and Robert Welch and Brian Staats and Eugenia E. Calle and Heather Spencer Feigelson and Michael J. Thun and Celestino D{\'i}az Rodr{\'i}guez and Demetrius Albanes and Jarmo R Virtamo and Stephanie J Weinstein and Fredrick R Schumacher and Edward L. Giovannucci and Walter C Willett and G{\'e}raldine Cancel-Tassin and Olivier Cussenot and Antoine Val{\'e}ri and Gerald L. Andriole and Edward P. Gelmann and Margaret Tucker and Daniela S. Gerhard and JosephF. Fraumeni and Robert Nathaniel Hoover and David J. Hunter and Stephen J. Chanock and George K. Thomas},
  journal={Nature Genetics},
  year={2007},
  volume={39},
  pages={645-649}
}
Recently, common variants on human chromosome 8q24 were found to be associated with prostate cancer risk. While conducting a genome-wide association study in the Cancer Genetic Markers of Susceptibility project with 550,000 SNPs in a nested case-control study (1,172 cases and 1,157 controls of European origin), we identified a new association at 8q24 with an independent effect on prostate cancer susceptibility. The most significant signal is 70 kb centromeric to the previously reported SNP… CONTINUE READING
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