Genome-wide association study of height-adjusted BMI in childhood identifies functional variant in ADCY3

@inproceedings{Stergiakouli2014GenomewideAS,
  title={Genome-wide association study of height-adjusted BMI in childhood identifies functional variant in ADCY3},
  author={Evangelia Stergiakouli and Rolf C. Gaillard and Jeremy M Tavar{\'e} and Nina Balthasar and Ruth J F Loos and Hendrik R. Taal and David M Evans and Fernando Rivadeneira and Beate St Pourcain and Andr{\'e} G. Uitterlinden and John P. Kemp and Albert Hofman and Susan M Ring and Tim James Cole and Vincent W. V. Jaddoe and George Davey Smith and Nicholas John Timpson},
  booktitle={Obesity},
  year={2014}
}
OBJECTIVE Genome-wide association studies (GWAS) of BMI are mostly undertaken under the assumption that "kg/m(2) " is an index of weight fully adjusted for height, but in general this is not true. The aim here was to assess the contribution of common genetic variation to a adjusted version of that phenotype which appropriately accounts for covariation in height in children. METHODS A GWAS of height-adjusted BMI (BMI[x] = weight/height(x) ), calculated to be uncorrelated with height, in 5809… CONTINUE READING
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