Genome-wide association study of epirubicin-induced leukopenia in Japanese patients.

OBJECTIVES Despite long-term clinical experience with epirubicin, unpredictable severe adverse reactions remain an important determinant to limit the drug use. To identify a genetic factor(s) affecting the risk of epirubicin-induced leukopenia/neutropenia, we performed a genome-wide association study. METHODS We studied 270 patients consisting of 67… CONTINUE READING