Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe

@inproceedings{Gnin2011GenomewideAS,
  title={Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe},
  author={Emmanuelle G{\'e}nin and Martin Schumacher and J. C. Roujeau and Luigi Naldi and Yvonne Liss and R{\'e}mi Kazma and Peggy Sekula and Alain Hovnanian and Maja Mockenhaupt},
  booktitle={Orphanet journal of rare diseases},
  year={2011}
}
BACKGROUND Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare but extremely severe cutaneous adverse drug reactions in which drug-specific associations with HLA-B alleles were described. OBJECTIVES To investigate genetic association at a genome-wide level on a large sample of SJS/TEN patients. METHODS We performed a genome wide association study on a sample of 424 European cases and 1,881 controls selected from a Reference Control Panel. RESULTS Six SNPs located… CONTINUE READING
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