Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

@inproceedings{Craddock2010GenomewideAS,
  title={Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls},
  author={Nicholas John Craddock and Matthew E. Hurles and Niall J. Cardin and Ryne Douglas Pearson and Vincent Plagnol and Samuel Gebhard Robson and D Vladan Vukcevic and Cl Barnes and Donald F. Conrad and Eleni Giannoulatou and Christopher R.J. Holmes and Jonathan L Marchini and Kari Stefansson and Martin D Tobin and Louise V Wain and Christopher Yau and Jan Aerts and Tariq Ahmad and Tracy D. Andrews and Hazel Arbury and Antony Paul Attwood and Adam Auton and Steve S. Ball and Anthony J. Balmforth and Jeffrey C. Barrett and In{\^e}s Barroso and Andrew J. Barton and A J Bennett and S. Venkata Udaya Bhaskar and Katarzyna Blaszczyk and John Bowes and Oliver J. Brand and Peter Stuart Braund and Francesca Bredin and Gerome Breen and Morris J. Brown and M Yvonne Alexander and Jaswinder Bull and Oliver S. Burren and J. Steven Burton and Jake K. Byrnes and Sharon Caesar and Chris Clee and Alison J. Coffey and John M. C. Connell and James Ph. D. Cooper and Anna F. Dominiczak and Kate Downes and Hazel E. Drummond and Darshna Dudakia and Andrew Dunham and Bernadette Ebbs and D. Roy EcclesD.R. Eccles and Jonathan R. Evans and Clarence Maurice Edwards and Anna Elliot and Patience Emery and Dennis J. Evans and Gareth Lloyd Evans and Steve de Eyre and Andrew D. Farmer and Ian Nicol Ferrier and Lars Feuk and Tomas W. Fitzgerald and Edward W. Flynn and Alexander M. Forbes and Liz Forty and Jayne A. Franklyn and Rachel M Freathy and Alex John James Miller and Paul Byron Gilbert and Omer Gokumen and Katherine Gordon-Smith and Elin S Gray and Elaine K Green and Christopher James Groves and Detelina Grozeva and Rhian Gwilliam and Alistair Scott Hall and Naomi Hammond and Matthew A. Hardy and Professor Alan Harrison and Neelam Hassanali and Husam Hebaishi and Karen A. Bennett and Anne Hinks and Graham A. Hitman and Lynne J. Hocking and Eleanor K. Howard and Philip J. Howard and Joanna M. M. Howson and Derralyn Hughes and Sarah Beth Hunt and John Isaacs and Miten Jain and Derek P. Jewell and Timothy Johnson and Jennifer Jolley and Ian R Jones and Lisa Jones and George Kirov and Christina G. Langford and Hana Lango-Allen and G. M. Lathrop and Jongdae Lee and Kate L. Lee and Charlie W. Lees and Kevin Hardy Andrew Lewis and Cecilia M. Lindgren and Meeta Maisuria-Armer and Julian B. Maller and John C. Mansfield and Pierre Martin and Dunecan C O Massey and Wendy L. Mcardle and Peter McGuffin and Kirsten E McLay and Alexander J. Mentzer and Michael L. Mimmack and Anna Morgan and Andrew Philip Morris and Craig Mowat and Simon Richard Myers and William G Newman and Elaine R. Nimmo and Michael C O'Donovan and Abiodun K Onipinla and Ifejinelo Onyiah and Nigel R. Ovington and Michael J Owen and Kimmo Palin and Kirstie S Parnell and David Pernet and John R. B. Perry and Andrew David Phillips and Daniela Pinto and Natalie J Prescott and Inga Prokopenko and Michael A. Quail and Suzanne E Rafelt and Nigel William Rayner and Richard Redon and D. McKinley Reid and Anthony Renwick and Valentina Iotchkova and Neil P. Robertson and Ellie Russell and David M. St Clair and Jennifer G. Sambrook and Jeremy A Sanderson and Helen Schuilenburg and Carol E. Scott and Rodney J. Scott and Sheila Seal and Sue Shaw-Hawkins and Beverley M Shields and Matthew James Simmonds and Deborah J. Smyth and Elilan Somaskantharajah and Katarina Spanova and Sophia Steer and Jeffrey. W. Stephens and Horace Nathaniel Stevens and Mc Stone and Zhan Su and Deborah Symmons and John R. Thompson and William. Thomson and Mary E. Travers and Clare Turnbull and Armand Valsesia and Mark J. Walker and Neil M. Walker and Chris Wallace and Margaret Warren-Perry and Nicholas Arthur Watkins and Jennifer A. Webster and Michael N. Weedon and Anthony G. Wilson and Matthew Woodburn and Bryan Paul Wordsworth and Anita Fernandez Young and Eleftheria Zeggini and Nigel P. Carter and Timothy M. Frayling and Cue Hyunkyu Lee and Gil McVean and Patricia B. Munroe and Aarno Palotie and Stephen J Sawcer and Stephen W. Scherer and D. P. Strachan and Chris Tyler-Smith and Michael R Brown and Paul R. Burton and Mark J. Caulfield and Alastair D Compston and Martin Farrall and Stephen C. L. Gough and Alisha S.M. Hall and Andrew T Hattersley and Archibald Vivian Hill and Christopher G. Mathew and Marcus E. Pembrey and Jack Satsangi and Michael R. Stratton and Jane Worthington and Panagiotis Deloukas and Audrey Duncanson and Dominic Kwiatkowski and Mark I. McCarthy and Willem H Ouwehand and Miles Parkes and Nazneen Rahman and John A. Todd and Nilesh J. Samani and Patrick Donnelly},
  year={2010}
}
Copy number variants (CNVs) account for a major proportion of human genetic polymorphism and have been predicted to have an important role in genetic susceptibility to common disease. To address this we undertook a large, direct genome-wide study of association between CNVs and eight common human diseases. Using a purpose-designed array we typed 19,000 individuals into distinct copy-number classes at 3,432 polymorphic CNVs, including an estimated 50% of all common CNVs larger than 500 base… CONTINUE READING

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