Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

  title={Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls},
  author={Paul R. Burton and David Clayton and Lon R. Cardon and Nick Craddock and Panos Deloukas and Audrey Duncanson and Dominic P. Kwiatkowski and Mark I. McCarthy and Willem Hendrik Ouwehand and Nilesh J. Samani and John A. Todd and Peter Donnelly and Jeffrey C. Barrett and Daniel B. Davison and Douglas Easton and David Evans and Hin-Tak Leung and Jonathan Marchini and Andrew P. Morris and Chris C. A. Spencer and Martin D. Tobin and Antony Paul Attwood and James P. Boorman and Barbara Cant and Ursula Everson and Judith M. Hussey and Jennifer D. Jolley and Alexandra S. Knight and Kerstin Koch and Elizabeth Meech and Sarah Nutland and Chris V. Prowse and Helen E. Stevens and Niall C. Taylor and G. Walters and Neil M. Walker and Nicholas Watkins and Thilo Winzer and Richard W Jones and Wendy L McArdle and Susan M. Ring and David P. Strachan and Marcus E Pembrey and Gerome D. Breen and David M. St. Clair and Sian Caesar and Katherine Gordon-Smith and Lisa A. Jones and Christine Fraser and Elaine K Green and Detelina Grozeva and Marian L. Hamshere and Peter A Holmans and Ian R. Jones and George Kirov and Valentina Moskvina and Ivan Nikolov and Michael C. O’Donovan and Michael J. Owen and David A. Collier and Amanda Elkin and Anne Farmer and Richard J. Williamson and Peter McGuffin and Allan H. Young and I. Nicol Ferrier and Stephen G. Ball and Anthony J. Balmforth and Jennifer H. Barrett and D. Timothy Bishop and Mark M. Iles and Azhar Maqbool and Nadira Y. Yuldasheva and Alistair S. Hall and Peter S Braund and Richard J. Dixon and Massimo Mangino and Suzanne E Stevens and John R. Thompson and Francesca Bredin and Mark Tremelling and Miles Parkes and Hazel E. Drummond and Charlie W. Lees and Elaine R. Nimmo and Jack Satsangi and Sheila A Fisher and Alastair Forbes and Cathryn M. Lewis and Clive M. Onnie and Natalie J Prescott and Jeremy D. Sanderson and Christopher G. Mathew and Jamie A Barbour and M Khalid Mohiuddin and Ce Todhunter and John C. Mansfield and Tariq Ahmad and Fraser Cummings and Derek P. Jewell and John Webster and Morris J. Brown and G. Mark Lathrop and John M. Connell and Anna F. Dominiczak and Carolina A. Braga Marcano and Beverley Burke and Richard J. B. Dobson and Johannie Gungadoo and Kate Lee and Patricia B. Munroe and Stephen J. Newhouse and Abiodun K Onipinla and Chris Wallace and Mingzhan Xue and Mark J. Caulfield and Martin Farrall and Anne Barton and Ian N. Bruce and Hannah Donovan and Stephen Eyre and Paul Gilbert and Samantha L. Hider and Anne Hinks and Sally L John and Catherine Potter and Alan J Silman and Deborah P M Symmons and Wendy Thomson and Jane Worthington and David B. Dunger and Barry Widmer and Timothy M. Frayling and Rachel M. Freathy and Hana Lango and John R. B. Perry and Beverley M. Shields and Michael N. Weedon and Andrew T. Hattersley and Graham A. Hitman and Mark Walker and Kate S. Elliott and Christopher J. Groves and Cecilia M. Lindgren and Nigel William Rayner and Nicholas John Timpson and Eleftheria Zeggini and Melanie J. Newport and Giorgio Sirugo and Emily J. Lyons and Fredrik O. Vannberg and Adrian V. S. Hill and Linda A. Bradbury and Claire Farrar and Jenny J. Pointon and Paul Wordsworth and Matthew A. Brown and Jayne A. Franklyn and Joanne M. Heward and Matthew J. Simmonds and Stephen C. L. Gough and Sheila Seal and Michael R. Stratton and Nazneen Rahman and Maria Ban and An Goris and Stephen J. Sawcer and Alastair Compston and David J. Conway and Muminatou Jallow and Kirk A. Rockett and Suzannah J. Bumpstead and Amy Chaney and Kate Downes and Mohammed J. R. Ghori and Rhian Gwilliam and Sarah E. Hunt and Michael Inouye and Andrew Keniry and Emma V. King and Ralph McGinnis and Simon C. Potter and Rathi Ravindrarajah and Pamela Whittaker and Claire Widden and David Withers and Niall J Cardin and Teresa Ferreira and Joanne Pereira-Gale and Ingileif B. Hallgr{\'i}msd{\'o}ttir and Bryan N. Howie and Zhan Su and Yik Ying Teo and Damjan Vukcevic and David L. Bentley and Alistair Compston},
There is increasing evidence that genome-wide association (GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We describe a joint GWA study (using the Affymetrix GeneChip 500K Mapping Array Set) undertaken in the British population, which has examined ∼2,000 individuals for each of 7 major diseases and a shared set of ∼3,000 controls. Case-control comparisons identified 24 independent association signals at P < 5 × 10-7: 1 in bipolar… 

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