Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

@article{Burton2007GenomewideAS,
  title={Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls},
  author={Paul R. Burton and David G. Clayton and Lon R. Cardon and Nicholas John Craddock and Panagiotis Deloukas and Audrey Duncanson and Dominic P Kwiatkowski and Mark I. McCarthy and Willem H Ouwehand and Nilesh J. Samani and John A. Todd and Peter Donnelly and Jeffrey C. Barrett and Dan Davison and D. Kenneth Easton and David M Evans and Hin-Tak Leung and Jonathan L. Marchini and Andrew P. Morris and Chris C A Spencer and Martin D Tobin and Antony Paul Attwood and James P. Boorman and Barbara Cant and Ursula Everson and Judith M. Hussey and Jennifer D M Jolley and Alexandra S. Knight and Kerstin Koch and Elizabeth Meech and Sarah Nutland and Christopher V. Prowse and Helen E. Stevens and Niall C. Taylor and Graham R. Walters and Neil M. Walker and Nicholas Arthur Watkins and Thilo Winzer and Richard W. M. Jones and Wendy L. Mcardle and Susan M Ring and David P. Strachan and Marcus E. Pembrey and Gerome Breen and David M. St Clair and S Julius Caesar and Katherine Gordon-Smith and Lisa Jones and Christine Marion Fraser and Elaine K Green and Detelina Grozeva and Marian Lindsay Hamshere and Peter Holmans and Ian Richard Jones and George Kirov and V. Moskvina and Ivan Nikolov and Michael C. O'Donovan and Michael J Owen and David A. Collier and Amanda Elkin and Adam D. Farmer and Richard Williamson and Peter McGuffin and Allan H Young and Ian Nicol Ferrier and Stephen G. Ball and Anthony J. Balmforth and Jennifer H. Barrett and D Timothy Bishop and Mark M. Iles and Azhar Maqbool and Nadira Y. Yuldasheva and Alistair Scott Hall and Peter Stuart Braund and Richard J. Dixon and Massimo Mangino and Suzanne H. Stevens and John R. Thompson and Francesca Bredin and M. J. Tremelling and Miles Parkes and Hazel E. Drummond and Charles W. Lees and Elaine R. Nimmo and Jack Satsangi and Sheila A. Fisher and Alastair H. Forbes and Cathryn M. Lewis and Clive M. Onnie and Natalie J Prescott and Jeremy A Sanderson and Christopher G Mathew and Jamie A Barbour and Mohhamed Khalid Mohiuddin and Catherine E. Todhunter and John C. Mansfield and Tariq Ahmad and Fraser R Cummings and Derek P. Jewell and John Lee Webster and S. Matthijs Boekholdt and G. Mark Lathrop and John M. C. Connell and Anna F. Dominiczak and Carolina A. Braga Marcano and Beverley Burke and Richard Dobson and Johannie Gungadoo and Kate L. Lee and Patricia B. Munroe and Stephen Newhouse and Abiodun K Onipinla and Chris Wallace and Mingzhan Xue and Mark J. Caulfield and Martin Farrall and Harlan N. Barton and M Yvonne Alexander and Hannah Donovan and Steve de Eyre and Paul Douglas Gilbert and Samantha L. Hider and Anne M. Hinks and Sally L. John and Christopher J. Potter and Alan J Silman and Deborah P M Symmons and W. Douglas Thomson and Jane Worthington and David B Dunger and Benjamin Widmer and Timothy M. Frayling and Rachel M Freathy and Hana Allen Lango and John R. B. Perry and Beverley M Shields and M. N. Weedon and Andrew T Hattersley and Graham A. Hitman and Mark Walker and Kate S. Elliott and Christopher James Groves and Cecilia M. Lindgren and Nigel William Rayner and Nicholas John Timpson and Eleftheria Zeggini and Melanie J. Newport and Giorgio Sirugo and Emily J. Lyons and Fredrik O. Vannberg and Adrian V S Hill and Linda A. Bradbury and Claire Farrar and Jennifer J. Pointon and Paul Wordsworth and Michael R Brown and Jayne A. Franklyn and Joanne M. Heward and Matthew James Simmonds and Stephen C. L. Gough and Sheila Seal and Michael R. Stratton and Nazneen Rahman and Maria Ban and An Goris and Stephen J Sawcer and Alastair D Compston and David J Conway and Muminatou Jallow and Kirk A. Rockett and Suzannah J. Bumpstead and Amy F. Chaney and Kate Downes and Mohammed J. R. Ghori and Rhian Gwilliam and Sarah E. Hunt and Michael Inouye and Andrew Keniry and Emma King and Ralph Y. McGinnis and Simon Richard Potter and Rathi Ravindrarajah and Pamela Whittaker and Claire Widden and David Withers and Niall J. Cardin and Teresa Jorge Ferreira and Joanne Pereira-Gale and Ingileif B. Hallgr{\'i}msd{\'o}ttir and Bryan Howie and Zhan Su and Yik Y. Teo and D Vladan Vukcevic and David R. Bentley and Alistair Compston},
  journal={Nature},
  year={2007},
  volume={447},
  pages={661-678}
}
There is increasing evidence that genome-wide association (GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We describe a joint GWA study (using the Affymetrix GeneChip 500K Mapping Array Set) undertaken in the British population, which has examined ∼2,000 individuals for each of 7 major diseases and a shared set of ∼3,000 controls. Case-control comparisons identified 24 independent association signals at P < 5 × 10-7: 1 in bipolar… CONTINUE READING
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