Genome-wide association study in essential tremor identifies three new loci

@inproceedings{Mueller2016GenomewideAS,
  title={Genome-wide association study in essential tremor identifies three new loci},
  author={Stefanie H Mueller and Simon L Girard and Franziska Hopfner and Nancy D Merner and Cynthia V. Bourassa and Delia Lorenz and Lorraine N. Clark and Lukas Tittmann and Alexandra I. Soto-Ortolaza and Stephan Klebe and Mark Hallett and S. A. Schneider and Colin Hodgkinson and Wolfgang Lieb and Zbigniew K Wszolek and Manuela Pendziwiat and Oswaldo Lorenzo-Betancor and Werner Poewe and Sara Ortega-Cubero and Klaus Seppi and Alex Rajput and Anna Hussl and Ali H. Rajput and D. Berg and Patrick A. Dion and Isabel Wurster and Joshua M Shulman and Karin Srulijes and Dietrich Haubenberger and Pau Pastor and Carles Vilari{\~n}o-G{\"u}ell and Ronald B. Postuma and Genevi{\`e}ve Bernard and K H Ladwig and Nicolas Dupre and Joseph Jankovic and Konstantin Strauch and Michel Panisset and Juliane Winkelmann and Claudia M. Testa and Eva Reischl and Kirsten E. Zeuner and Owen A. Ross and Thomas Arzberger and Sylvain Chouinard and Guenther Deuschl and Elan Daniel Louis and Gregor Kuhlenbaeumer and Guy Rouleau},
  booktitle={Brain : a journal of neurology},
  year={2016}
}
We conducted a genome-wide association study of essential tremor, a common movement disorder characterized mainly by a postural and kinetic tremor of the upper extremities. Twin and family history studies show a high heritability for essential tremor. The molecular genetic determinants of essential tremor are unknown. We included 2807 patients and 6441 controls of European descent in our two-stage genome-wide association study. The 59 most significantly disease-associated markers of the… CONTINUE READING
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