Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

@article{Han2009GenomewideAS,
  title={Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus},
  author={Jian-Wen Han and Hou-Feng Zheng and Yong Cui and Liang-dan Sun and Dq Ye and Zhi Hu and Jin-hua Xu and Zhi-ming Cai and Wei Liang Huang and Guo-Ping Zhao and Hong-fu Xie and Hong Yuan Fang and Qian-jin Lu and Jian-hua Xu and Xiang-Pei Li and Yun-feng Pan and Dan-qi Deng and Fan-qin Zeng and Zhi-zhong Ye and Xiao-Yan Zhang and Qing-wen Wang and Fei Hao and Li Ma and Xian-bo Zuo and Fu-sheng Zhou and Wen-Hui Du and Yi-lin Cheng and Jian-Qiang Yang and Song-Ke Shen and Jian Li and Yu-jun Sheng and Xiaoxia Zuo and Wei-fang Zhu and Fei Gao and Pei-Lian Zhang and Qing Yang Guo and Bo Li and Min Gao and Feng-li Xiao and Cheng Xi Quan and Chi Zhang and Zheng Zhang and Kun-ju Zhu and Yang Li and Da-yan Hu and Wen-sheng Lu and Jian-lin Huang and Sheng-Xiu Liu and Hui Li and Yun-qing Ren and Zai-xing Wang and Chun-Jun Yang and Pei-Guang Wang and Wen-ming Zhou and Yong-mei Lv and An-ping Zhang and Sheng-quan Zhang and Da Lin and Yi Li and Hui Qi Low and Min Shen and Zhi-Fang Zhai and Ying Wang and Feng-yu Zhang and Sen Yang and Jian-Jun Liu and Xue-jun Zhang},
  journal={Nature Genetics},
  year={2009},
  volume={41},
  pages={1234-1237}
}
We performed a genome-wide association study (GWAS) of systemic lupus erythematosus (SLE) in a Chinese Han population by genotyping 1,047 cases and 1,205 controls using Illumina Human610-Quad BeadChips and replicating 78 SNPs in two additional cohorts (3,152 cases and 7,050 controls). We identified nine new susceptibility loci (ETS1, IKZF1, RASGRP3, SLC15A4, TNIP1, 7q11.23, 10q11.22, 11q23.3 and 16p11.2; 1.77 × 10−25 ≤ Pcombined ≤ 2.77 × 10−8) and confirmed seven previously reported loci (BLK… CONTINUE READING
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Genetic susceptibility to SLE : new insights from fine mapping and genome - wide association studies

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