Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease

@article{Lu2012GenomewideAS,
  title={Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease},
  author={Xiangfeng Lu and Laiyuan Wang and Shufeng Chen and Lin He and Xueli Yang and Yongyong Shi and Jing Cai Cheng and Liang Zhang and Chi Charles Gu and Jianfeng Huang and Tangchun Wu and Yitong Ma and Jianxin Li and Jie Cao and Junshi Chen and Dongliang Ge and Zhongjie Fan and Ying Li and Liancheng Zhao and Hongfan Li and Xiaoyang Zhou and Lanying Chen and Donghua Liu and Jingping Chen and Xiu-fang Duan and Yongchen Hao and Ligui Wang and Fanghong Lu and Zhendong Liu and Cailiang Yao and Chong Shen and Xiaodong Pu and Lin Yu and Xianghua Fang and Lihua Xu and Jianjun Mu and Xianping Wu and Runping Zheng and Naqiong Wu and Qi Zhao and Yun Li and Xiaoli Liu and Mengqin Wang and Dahai Yu and Dongsheng Hu and Xu Yin Ji and Dongshuang Guo and Dongling Sun and Qianqian Wang and Ying Yang and Fangchao Liu and Qunxia Mao and Xiaohua Liang and Jingfeng Ji and Panpan Chen and Xingbo Mo and Dianjiang Li and Guoping Chai and Yida Tang and Xiangdong Li and Zhenhan Du and Xuehui Liu and Chenlong Dou and Zili Yang and Qingjie Meng and Dong Wang and Renping Wang and Jun Yang and Heribert Schunkert and Nilesh J. Samani and Sekar Kathiresan and Muredach P. Reilly and Jeanette Erdmann and Xiaozhong Peng and Xigui Wu and Depei Liu and Yuejin Yang and Runsheng Chen and Boqin Qiang and Dongfeng Gu},
  journal={Nature Genetics},
  year={2012},
  volume={44},
  pages={890-894}
}
We performed a meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 cases and 11,472 controls, all of Chinese Han ancestry. We identify four new loci for coronary artery disease that reached the threshold of genome-wide significance (P < 5 × 10−8). These loci mapped in or near TTC32-WDR35, GUCY1A3, C6orf10-BTNL2 and ATP2B1. We also replicated four loci previously identified in European… CONTINUE READING
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