Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome.

  title={Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome.},
  author={Malte Christoph R{\"u}hlemann and Britt M. Hermes and Corinna Bang and Shauni Doms and Lucas Moitinho-Silva and Louise B Thingholm and Fabian Frost and Frauke Degenhardt and Michael Wittig and Jan Christian K{\"a}ssens and Frank Ulrich Weiss and Annette Peters and Klaus Neuhaus and Uwe V{\"o}lker and Henry V{\"o}lzke and Georg Homuth and Stefan Weiss and Harald Grallert and Matthias Laudes and Wolfgang Lieb and Dirk Haller and Markus M. Lerch and John F. Baines and Andr{\'e} Franke},
  journal={Nature genetics},
The intestinal microbiome is implicated as an important modulating factor in multiple inflammatory1,2, neurologic3 and neoplastic diseases4. Recent genome-wide association studies yielded inconsistent, underpowered and rarely replicated results such that the role of human host genetics as a contributing factor to microbiome assembly and structure remains uncertain5-11. Nevertheless, twin studies clearly suggest host genetics as a driver of microbiome composition11. In a genome-wide association… 

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Author Correction: Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project

A genome-wide association study of 207 taxa and 205 pathways representing microbial composition and function in 7,738 participants of the Dutch Microbiome Project found two robust, study-wide significant signals near the LCT and ABO genes were found to be associated with multiple microbialTaxa and pathways and were replicated in two independent cohorts.

Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project

A genome-wide association study within the Dutch Microbiome Project, a population cohort of 7,738 individuals from the northern Netherlands, found two robust, study-wide significant signals near the LCT and ABO genes were found to affect multiple microbial taxa and pathways, and were replicated in two independent cohorts.

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