Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome.

@article{Rhlemann2021GenomewideAS,
  title={Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome.},
  author={Malte Christoph R{\"u}hlemann and Britt M. Hermes and Corinna Bang and Shauni Doms and Lucas Moitinho-Silva and Louise B Thingholm and Fabian Frost and Frauke Degenhardt and Michael Wittig and Jan Christian K{\"a}ssens and Frank Ulrich Weiss and Annette Peters and Klaus Neuhaus and Uwe V{\"o}lker and Henry V{\"o}lzke and Georg Homuth and Stefan Weiss and Harald Grallert and Matthias Laudes and Wolfgang Lieb and Dirk Haller and Markus M. Lerch and John F. Baines and Andr{\'e} Franke},
  journal={Nature genetics},
  year={2021}
}
The intestinal microbiome is implicated as an important modulating factor in multiple inflammatory1,2, neurologic3 and neoplastic diseases4. Recent genome-wide association studies yielded inconsistent, underpowered and rarely replicated results such that the role of human host genetics as a contributing factor to microbiome assembly and structure remains uncertain5-11. Nevertheless, twin studies clearly suggest host genetics as a driver of microbiome composition11. In a genome-wide association… 

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References

SHOWING 1-10 OF 49 REFERENCES

Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota

Genome-wide significant associations for overall microbial variation and individual taxa at multiple genetic loci identify other important points of host–microbe intersection, notably several disease susceptibility genes and sterol metabolism pathway components.

Genome-Wide Association Studies of the Human Gut Microbiota

This study examined the association of ~200K host genotypes with the relative abundance of fecal bacterial taxa in a founder population, the Hutterites, during two seasons and identified tissues in which host genetic variation may be acting to influence bacterial abundance in the gut.

The effect of host genetics on the gut microbiome

The results demonstrate the importance of understanding host–microbe interactions to gain better insight into human health and demonstrate the influence of host genetics on microbial species, pathways and gene ontology categories on the basis of metagenomic sequencing in 1,514 subjects.

Environment dominates over host genetics in shaping human gut microbiota

Genotype and microbiome data from 1,046 healthy individuals with several distinct ancestral origins who share a relatively common environment are examined, and it is demonstrated that the gut microbiome is not significantly associated with genetic ancestry, and that host genetics have a minor role in determining microbiome composition.

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

A meta-analysis of Crohn’s disease and ulcerative colitis genome-wide association scans is undertaken, followed by extensive validation of significant findings, with a combined total of more than 75,000 cases and controls.

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

The first trans-ancestry association study of IBD is reported, with genome-wide or Immunochip genotype data from an extended cohort of 86,640 European individuals and immunochip data from 9,846 individuals of East Asian, Indian or Iranian descent, implicate 38 loci in IBD risk for the first time.

Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

This work identified 25 new susceptibility loci, 3 of which contain integrin genes that encode proteins in pathways that have been identified as important therapeutic targets in inflammatory bowel disease and identified 3 associated variants that are correlated with expression changes in response to immune stimulus at two of these genes.

Colonic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 (Secretor) genotype

Findings indicate that alterations in resident microbial communities may in part explain the variety of host susceptibilities surrounding nonsecretor status and that FUT2 is an important genetic factor influencing host–microbial diversity.