Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome.

@article{Rhlemann2021GenomewideAS,
  title={Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome.},
  author={Malte Christoph R{\"u}hlemann and Britt M. Hermes and Corinna Bang and Shauni Doms and L Moitinho-Silva and Louise B Thingholm and Fabian Frost and Frauke Degenhardt and Michael Wittig and Jan Christian K{\"a}ssens and Frank Ulrich Weiss and Annette Peters and Klaus Neuhaus and Uwe V{\"o}lker and Henry V{\"o}lzke and Georg Homuth and Stefan Weiss and Harald Grallert and Matthias Laudes and Wolfgang Lieb and Dirk Haller and Markus M. Lerch and John F. Baines and Andr{\'e} Franke},
  journal={Nature genetics},
  year={2021}
}
The intestinal microbiome is implicated as an important modulating factor in multiple inflammatory1,2, neurologic3 and neoplastic diseases4. Recent genome-wide association studies yielded inconsistent, underpowered and rarely replicated results such that the role of human host genetics as a contributing factor to microbiome assembly and structure remains uncertain5-11. Nevertheless, twin studies clearly suggest host genetics as a driver of microbiome composition11. In a genome-wide association… 
Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project
TLDR
A genome-wide association study within the Dutch Microbiome Project, a population cohort of 7,738 individuals from the northern Netherlands, found two robust, study-wide significant signals near the LCT and ABO genes were found to affect multiple microbial taxa and pathways, and were replicated in two independent cohorts.
Host Genetics and Gut Microbiome: Perspectives for Multiple Sclerosis
TLDR
The current knowledge on genetic factors related to MS is described, based on genome-wide association studies, and the interactions between the immune system, gut microbiome and central nervous system in MS are illustrated, summarizing the evidence available from Experimental Autoimmune Encephalomyelitis mouse models and studies in patients.
Key features of the genetic architecture and evolution of host-microbe interactions revealed by high-resolution genetic mapping of the mucosa-associated gut microbiome in hybrid mice
TLDR
A powerful genetic mapping approach is employed using inbred lines derived from the hybrid zone of two incipient house mouse species to identify an enrichment of candidate genes associated with several human diseases, including inflammatory bowel disease, and functional categories including innate immunity and G-protein-coupled receptors.
Systems genetics uncovers microbe-lipid-host connections in the murine gut
TLDR
Quantitative trait loci analysis identified genomic regions associated with variations in bacterial taxa, bacterial functions, including motility, sporulation and lipopolysaccharide production, and levels of bacterial- and host-derived lipids that influence microbe-host dynamics.
The Spanish gut microbiome reveals links between microorganisms and Mediterranean diet
TLDR
Overall, this study describes the Spanish “normal” microbiome, providing a solid baseline for future studies investigating the effects of gut microbiome composition and deviations in the adherence to the Mediterranean diet.
Quantifying the Impact of Human Leukocyte Antigen on the Human Gut Microbiota
TLDR
A significant impact of the HLA on the human gut microbiota is indicated, and the results open the door to incorporating the genetics of the immune system into predictive microbiome models.
The power and potential of BIOMAP to elucidate host‐microbiome interplay in skin inflammatory diseases
TLDR
A review highlights the power and potential of BIOMAP project in the investigation of microbe-host interplay in AD and psoriasis and identifies potential biomarkers responsible for the variation in disease outcome.
General Unified Microbiome Profiling Pipeline (GUMPP) for Large Scale, Streamlined and Reproducible Analysis of Bacterial 16S rRNA Data to Predicted Microbial Metagenomes, Enzymatic Reactions and Metabolic Pathways
General Unified Microbiome Profiling Pipeline (GUMPP) was developed for large scale, streamlined and reproducible analysis of bacterial 16S rRNA data and prediction of microbial metagenomes,
IBD AND THE GUT MICROBIOTA
A clinical trial aimed to compare the effects of a low-fat and high-fibre diet and the effects of an improved standard American diet on quality of life, markers of inflammation and faecal markers of
...
1
2
...

References

SHOWING 1-10 OF 54 REFERENCES
Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota
TLDR
Genome-wide significant associations for overall microbial variation and individual taxa at multiple genetic loci identify other important points of host–microbe intersection, notably several disease susceptibility genes and sterol metabolism pathway components.
Genetic Determinants of the Gut Microbiome in UK Twins.
TLDR
The results indicate that diet-sensing, metabolism, and immune defense are important drivers of human-microbiome co-evolution.
Genome-Wide Association Studies of the Human Gut Microbiota
TLDR
This study examined the association of ~200K host genotypes with the relative abundance of fecal bacterial taxa in a founder population, the Hutterites, during two seasons and identified tissues in which host genetic variation may be acting to influence bacterial abundance in the gut.
Application of the distance-based F test in an mGWAS investigating β diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci
TLDR
This work reports on the application of a new method for genotype-β-diversity association testing, the distance-based F (DBF) test, and identifies 4 loci with genome-wide significant associations, harboring the genes CBEP4, SLC9A8, TNFSF4, and SP140, respectively.
The effect of host genetics on the gut microbiome
TLDR
The results demonstrate the importance of understanding host–microbe interactions to gain better insight into human health and demonstrate the influence of host genetics on microbial species, pathways and gene ontology categories on the basis of metagenomic sequencing in 1,514 subjects.
Environment dominates over host genetics in shaping human gut microbiota
TLDR
Genotype and microbiome data from 1,046 healthy individuals with several distinct ancestral origins who share a relatively common environment are examined, and it is demonstrated that the gut microbiome is not significantly associated with genetic ancestry, and that host genetics have a minor role in determining microbiome composition.
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
TLDR
A meta-analysis of Crohn’s disease and ulcerative colitis genome-wide association scans is undertaken, followed by extensive validation of significant findings, with a combined total of more than 75,000 cases and controls.
Association of host genome with intestinal microbial composition in a large healthy cohort
TLDR
It is found that almost one-third of fecal bacterial taxa were heritable, and 58 SNPs associated with the relative abundance of 33 taxa in 1,098 discovery subjects remained significant after correction for multiple testing.
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
TLDR
The first trans-ancestry association study of IBD is reported, with genome-wide or Immunochip genotype data from an extended cohort of 86,640 European individuals and immunochip data from 9,846 individuals of East Asian, Indian or Iranian descent, implicate 38 loci in IBD risk for the first time.
...
1
2
3
4
5
...