Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease.

  title={Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease.},
  author={Gary W. Beecham and Eden R. Martin and Yi-Ju Li and Michael A. Slifer and John R. Gilbert and Jonathan L. Haines and Margaret A. Pericak-Vance},
  journal={American journal of human genetics},
  volume={84 1},
Only Apolipoprotein E polymorphisms have been consistently associated with the risk of late-onset Alzheimer disease (LOAD), but they represent only a minority of the underlying genetic effect. To identify additional LOAD risk loci, we performed a genome-wide association study (GWAS) on 492 LOAD cases and 498 cognitive controls using Illumina's HumanHap550 beadchip. An additional 238 cases and 220 controls were used as a validation data set for single-nucleotide polymorphisms (SNPs) that met… CONTINUE READING
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