Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R/IL12RB2 regions associated with Behçet's disease

  title={Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R/IL12RB2 regions associated with Behçet's disease},
  author={Elaine F. Remmers and Fulya Coşan and Yohei Kirino and Michael J Ombrello and Neslihan Abaci and Colleen L Satorius and Julie M. Le and Barbara Yang and Benjamin D. Korman and Aris Çakiris and Oznur Aglar and Zeliha Emrence and Hulya Azakli and Duran Ustek and İlknur Tuğal-Tutkun and Gulsen Akman-Demir and Wei Chen and Christopher I. Amos and Michael B. Dizon and Afet Akdag Kose and Gulsevim Azizlerli and Burak Erer and Oliver J. Brand and Virginia G. Kaklamani and Phaedon G. Kaklamanis and Eldad Ben-Ch{\'e}trit and Miles R Stanford and Farida Fortune and Marwen Ghabra and William E. R. Ollier and Young-hun Cho and Dongsik Bang and John J O'Shea and Graham R. Wallace and Massimo Gadina and Daniel L. Kastner and Ahmet G{\"u}l},
  booktitle={Nature Genetics},
Behçet's disease is a genetically complex disease of unknown etiology characterized by recurrent inflammatory attacks affecting the orogenital mucosa, eyes and skin. We performed a genome-wide association study with 311,459 SNPs in 1,215 individuals with Behçet's disease (cases) and 1,278 healthy controls from Turkey. We confirmed the known association of Behçet's disease with HLA-B*51 and identified a second, independent association within the MHC Class I region. We also identified an… CONTINUE READING
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