Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

@article{Lambert2009GenomewideAS,
  title={Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease},
  author={Jean-Charles Lambert and Simon C. Heath and Ga{\"e}l Even and Dominique Campion and Kristel Sleegers and Mikko Hiltunen and Onofre Combarros and Diana Z{\'e}l{\'e}nika and Maria Jesus Bullido and B{\'e}atrice Tavernier and Luc Letenneur and Karolien Bettens and Claudine Berr and Florence Pasquier and Nathalie Fievet and Pascale Barberger‐Gateau and Sebastiaan Engelborghs and Peter Paul De Deyn and Ignacio Mateo and A Franck and S. Helisalmi and Elisa Porcellini and Olivier Hanon and Marian M. Pancorbo and Corinne L. Lendon and Carole Dufouil and Céline Jaillard and Thierry L{\'e}veillard and Victoria {\'A}lvarez and Paolo Bosco and Michelangelo Mancuso and Francesco Panza and Benedetta Nacmias and Paola Boss{\`u} and Paola Piccardi and Giorgio Annoni and Davide Seripa and Daniela Galimberti and Didier Hannequin and Federico Licastro and Hilkka Soininen and Karen Ritchie and H{\'e}l{\`e}ne Blanch{\'e} and Jean-François Dartigues and Christophe Tzourio and Ivo Glynne Gut and Christine Van Broeckhoven and Annick Alp{\'e}rovitch and Mark G. Lathrop and Philippe Amouyel},
  journal={Nature Genetics},
  year={2009},
  volume={41},
  pages={1094-1099}
}
The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed susceptibility locus for late-onset Alzheimer's disease. To identify other risk loci, we conducted a large genome-wide association study of 2,032 individuals from France with Alzheimer's disease (cases) and 5,328 controls. Markers outside APOE with suggestive evidence of association (P < 10−5) were examined in collections from Belgium, Finland, Italy and Spain totaling 3,978 Alzheimer's disease cases and 3,297… Expand
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease, and shows evidence for additional susceptibility genes
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Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
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A two-stage genome-wide association study of Alzheimer's disease involving over 16,000 individuals, the most powerful AD GWAS to date, produced compelling evidence for association with Alzheimer’s disease in the combined dataset. Expand
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