Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate

@article{Mangold2010GenomewideAS,
  title={Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate},
  author={Elisabeth Mangold and Kerstin U. Ludwig and Stefanie Birnbaum and Carlotta Baluardo and Melissa Ferrian and Stefan Herms and Heiko M Reutter and Nilma Almeida de Assis and Taofik Al Chawa and Manuel Mattheisen and Michael Steffens and Sandra Barth and Nadine Kluck and Anna R. Paul and Jessica Becker and Carola Lauster and G{\"u}l Schmidt and Bert Braumann and Martin Scheer and Rudolf Hermann Reich and Alexander Hemprich and Simone Poetzsch and Bettina Blaumeiser and Susanne Moebus and Michael Krawczak and Stefan Schreiber and Thomas Meitinger and H Erich Wichmann and R{\'e}gine P M Steegers-Theunissen and F. -J. Kramer and Sven Cichon and P. Propping and Thomas F. Wienker and Michael Knapp and Michele Rubini and Peter Anthony Mossey and Per Hoffmann and Markus M. N{\"o}then},
  journal={Nature Genetics},
  year={2010},
  volume={42},
  pages={24-26}
}
We conducted a genome-wide association study for nonsyndromic cleft lip with or without cleft palate (NSCL/P) in 401 affected individuals and 1,323 controls, with replication in an independent sample of 793 NSCL/P triads. We report two new loci associated with NSCL/P at 17q22 (rs227731, combined P = 1.07 × 10−8, relative risk in homozygotes = 1.84, 95% CI 1.34–2.53) and 10q25.3 (rs7078160, combined P = 1.92 × 10−8, relative risk in homozygotes = 2.17, 95% CI 1.32–3.56). 
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