Genome-wide association study identifies three common variants associated with serologic response to vitamin E supplementation in men.

@article{Major2012GenomewideAS,
  title={Genome-wide association study identifies three common variants associated with serologic response to vitamin E supplementation in men.},
  author={Jacqueline M Major and Kai Yu and Charles Y. C. Chung and Stephanie J Weinstein and Meredith Yeager and William Wheeler and K. F. Snyder and Margaret E. Wright and Jarmo R Virtamo and Stephen K Chanock and Demetrius Albanes},
  journal={The Journal of nutrition},
  year={2012},
  volume={142 5},
  pages={866-71}
}
Vitamin E inhibits lipid peroxidation in cell membranes, prevents oxidative damage to DNA by scavenging free radicals, and reduces carcinogen production. No study to our knowledge, however, has examined the association between genetic variants and response to long-term vitamin E supplementation. We conducted a genome-wide association study (GWAS) of common variants associated with circulating α-tocopherol concentrations following 3 y of controlled supplementation. The study population included… CONTINUE READING
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