Genome-wide association study identifies three novel loci for type 2 diabetes.

  title={Genome-wide association study identifies three novel loci for type 2 diabetes.},
  author={Kazuo Hara and Hayato Fujita and Todd A Johnson and Toshimasa Yamauchi and Kazuki Yasuda and Momoko Horikoshi and Chen Peng and Cheng Hu and Ronald C. W. Ma and Minako Imamura and Minoru Iwata and Tatsuhiko Tsunoda and Takashi Morizono and Nobuhiro Shojima and Wing-Yee So and Ting Fan Leung and Patrick Kwan and Rong Zhang and Jie Wang and Weihui Yu and Hiroshi Maegawa and Hiroshi Hirose and Kohei Kaku and Chikako Ito and Hirotaka Watada and Yasushi Tanaka and Kazuyuki Tobe and Atsunori Kashiwagi and Ryuzo Kawamori and Weiping Jia and Juliana C. N. Chan and Yik Y. Teo and Tai E Shyong and Naoyuki Kamatani and Michiaki Kubo and Shiro Maeda and Takashi Kadowaki},
  journal={Human molecular genetics},
  volume={23 1},
Although over 60 loci for type 2 diabetes (T2D) have been identified, there still remains a large genetic component to be clarified. To explore unidentified loci for T2D, we performed a genome-wide association study (GWAS) of 6 209 637 single-nucleotide polymorphisms (SNPs), which were directly genotyped or imputed using East Asian references from the 1000 Genomes Project (June 2011 release) in 5976 Japanese patients with T2D and 20 829 nondiabetic individuals. Nineteen unreported loci were… CONTINUE READING
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