Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.

@article{Wu2013GenomewideAS,
  title={Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.},
  author={Jason H. Y. Wu and Rozenn N Lemaitre and Ani Manichaikul and Weihua Guan and Toshiko Tanaka and Millennia Foy and Edmond K Kabagambe and Luc Djouss{\'e} and David S Siscovick and Amanda M Fretts and Catherine O. Johnson and Irena B. King and Bruce M. Psaty and Barbara Mcknight and Stephen S. Rich and Yii-Der I. Chen and Jennifer A. Nettleton and Weihong Tang and Stefania Bandinelli and David R. Jacobs and Brian L. Browning and Cathy C. Laurie and Xiangjun Gu and Michael Tsai and Lyn M. Steffen and Luigi Ferrucci and Myriam Fornage and Dariush Mozaffarian},
  journal={Circulation. Cardiovascular genetics},
  year={2013},
  volume={6 2},
  pages={171-83}
}
BACKGROUND- Palmitic acid (16:0), stearic acid (18:0), palmitoleic acid (16:1n-7), and oleic acid (18:1n-9) are major saturated and monounsaturated fatty acids that affect cellular signaling and metabolic pathways. They are synthesized via de novo lipogenesis and are the main saturated and monounsaturated fatty acids in the diet. Levels of these fatty acids… CONTINUE READING