Genome-wide association study identifies multiple susceptibility loci for glioma

  title={Genome-wide association study identifies multiple susceptibility loci for glioma},
  author={Ben Kinnersley and Marianne Labussi{\`e}re and Amy Holroyd and Anna Luisa Di Stefano and Peter Broderick and Jayaram Vijayakrishnan and Karima Mokhtari and Jean-Yves Delattre and Konstantinos Gousias and Johannes Schramm and Minouk J Schoemaker and Sarah J. Fleming and Stefan Herms and Stefanie Heilmann and Stefan Schreiber and Heinz-Erich Wichmann and Markus M. N{\"o}then and Anthony J. Swerdlow and Mark G. Lathrop and Matthias Simon and Melissa L Bondy and Marc Sanson and Richard S. Houlston},
  journal={Nature Communications},
Previous genome-wide association studies (GWASs) have shown that common genetic variation contributes to the heritable risk of glioma. To identify new glioma susceptibility loci, we conducted a meta-analysis of four GWAS (totalling 4,147 cases and 7,435 controls), with imputation using 1000 Genomes and UK10K Project data as reference. After genotyping an additional 1,490 cases and 1,723 controls we identify new risk loci for glioblastoma (GBM) at 12q23.33 (rs3851634, near POLR3B, P=3.02 × 10−9… 

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