Genome-wide association study identifies multiple susceptibility loci for glioma

@article{Kinnersley2015GenomewideAS,
  title={Genome-wide association study identifies multiple susceptibility loci for glioma},
  author={B. Kinnersley and M. Labussi{\`e}re and A. Holroyd and A. D. Di Stefano and P. Broderick and J. Vijayakrishnan and K. Mokhtari and J. Delattre and K. Gousias and J. Schramm and M. Schoemaker and Sarah J. Fleming and S. Herms and S. Heilmann and S. Schreiber and H. Wichmann and M. N{\"o}then and A. Swerdlow and M. Lathrop and M. Simon and M. Bondy and M. Sanson and R. Houlston},
  journal={Nature Communications},
  year={2015},
  volume={6}
}
Previous genome-wide association studies (GWASs) have shown that common genetic variation contributes to the heritable risk of glioma. To identify new glioma susceptibility loci, we conducted a meta-analysis of four GWAS (totalling 4,147 cases and 7,435 controls), with imputation using 1000 Genomes and UK10K Project data as reference. After genotyping an additional 1,490 cases and 1,723 controls we identify new risk loci for glioblastoma (GBM) at 12q23.33 (rs3851634, near POLR3B, P=3.02 × 10−9… Expand
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