Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3

@article{Chen2011GenomewideAS,
  title={Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3},
  author={Zi-Jiang Chen and Han Zhao and Lin He and YuHua Shi and Yingying Qin and Yongyong Shi and Zhiqiang Li and Li You and Junli Zhao and Jiayin Liu and Xiaoyan Liang and Xiaoming Zhao and Jun-zhao Zhao and Ying-pu Sun and Bo Zhang and Hong Jiang and Dongni Zhao and Yuehong Bian and Xuan Gao and Ling Geng and Yiran Li and Dongyi Zhu and Xiuqin Sun and Jin-e Xu and Cuifang Hao and Chun-e Ren and Yajie Zhang and Shi-ling Chen and Wei Zhang and Aijun Yang and Junhao Yan and Yuan Zheng Li and Jinlong Ma and Yueran Zhao},
  journal={Nature Genetics},
  year={2011},
  volume={43},
  pages={55-59}
}
Polycystic ovary syndrome (PCOS) is a common metabolic disorder in women. To identify causative genes, we conducted a genome-wide association study (GWAS) of PCOS in Han Chinese. The discovery set included 744 PCOS cases and 895 controls; subsequent replications involved two independent cohorts (2,840 PCOS cases and 5,012 controls from northern Han Chinese; 498 cases and 780 controls from southern and central Han Chinese). We identified strong evidence of associations between PCOS and three… CONTINUE READING
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Genome-wide association study in alopecia areata implicates both innate and adaptive immunity

  • L Petukhova
  • Nature 466,
  • 2010

Genetic polymorphisms of GnRH and gonadotrophic hormone receptors affect the phenotype of polycystic ovary syndrome

  • O Valkenburg
  • Hum. Reprod
  • 2009

Genomic dissection of population substructure of Han Chinese and its implication in association studies

  • S Xu
  • Am. J. Hum. Genet
  • 2009

Metabolic syndrome and polycystic ovary syndrome ... ; and vice versa

  • S. Wild, T. Pierpoint, H. Jacobs, P. McKeigue
  • Arq . Bras . Endocrinol . Metabol .
  • 2009

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