Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: The HyperGEN Study

@article{Arnett2008GenomewideAS,
  title={Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: The HyperGEN Study},
  author={Donna K Arnett and Na Li and Weihong Tang and D. Chandrasekhra Rao and Richard Blyton Devereux and Steven A. Claas and Rachel Kraemer and Ulrich Broeckel},
  journal={BMC Medical Genetics},
  year={2008},
  volume={10},
  pages={43 - 43}
}
We conducted a genome-wide association study (GWAS) and validation study for left ventricular (LV) mass in the Family Blood Pressure Program – HyperGEN population. LV mass is a sensitive predictor of cardiovascular mortality and morbidity in all genders, races, and ages. Polymorphisms of candidate genes in diverse pathways have been associated with LV mass. However, subsequent studies have often failed to replicate these associations. Genome-wide association studies have unprecedented power to… CONTINUE READING
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