Genome-wide association study identifies five susceptibility loci for glioma

@article{Shete2009GenomewideAS,
  title={Genome-wide association study identifies five susceptibility loci for glioma},
  author={Sanjay Shete and Fay J. Hosking and Lindsay B. Robertson and Sara E Dobbins and Marc Sanson and Beatrice Malmer and Matthias Simon and Yannick Marie and Blandine Boisselier and Jean-Yves Delattre and Khe Hoang-Xuan and Soufiane El Hallani and Ahmed Idbaih and Diana Z{\'e}l{\'e}nika and Ulrika Andersson and Roger Henriksson and A. Tommy Bergenheim and Maria Feychting and Stefan Lönn and Anders Ahlbom and Johannes Schramm and Michael Linnebank and Kari Hemminki and Ravindra Kumar and Sarah J. Hepworth and Amy Price and Georgina N. Armstrong and Yanhong Liu and Xiangjun Gu and Robert K. Yu and Ching C. Lau and Minouk J Schoemaker and Kenneth Ross Muir and Anthony J. Swerdlow and Mark G. Lathrop and Melissa L Bondy and Richard S. Houlston},
  journal={Nature Genetics},
  year={2009},
  volume={41},
  pages={899-904}
}
To identify risk variants for glioma, we conducted a meta-analysis of two genome-wide association studies by genotyping 550K tagging SNPs in a total of 1,878 cases and 3,670 controls, with validation in three additional independent series totaling 2,545 cases and 2,953 controls. We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 × 10−17), 8q24.21 (rs4295627, CCDC26; P = 2.34 × 10−18), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 × 10−15), 20q13.33 (rs6010620, RTEL1; P… Expand
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