Genome-wide association study identifies five loci associated with lung function

@article{Repapi2010GenomewideAS,
  title={Genome-wide association study identifies five loci associated with lung function},
  author={Emmanouela Repapi and Ian Sayers and Louise V Wain and Paul R. Burton and Toby Johnson and Ma'en Obeidat and Jing Hua Zhao and Adaikalavan Ramasamy and Guangju Zhai and Veronique Vitart and Jennifer E Huffman and Wilmar Igl and Eva Albrecht and Panos Deloukas and John Henderson and Raquel Granell and Wendy L. Mcardle and Alicja R. Rudnicka and In{\^e}s Barroso and Ruth J F Loos and Nicholas J Wareham and L Mustelin and Taina Rantanen and Ida Surakka and Medea Imboden and H Erich Wichmann and Ivica Grkovic and Stipan Jankovic and Lina Zgaga and Anna-Liisa Hartikainen and Leena Peltonen and Ulf Gyllensten and {\AA}sa Johansson and Ghazal Zaboli and Harry Campbell and Sarah H Wild and James F Wilson and Sven Gl{\"a}ser and Georg Homuth and Henry V{\"o}lzke and Massimo Mangino and Nicole Soranzo and Tim D. Spector and Ozren Pola{\vs}ek and Igor Rudan and Alan F. Wright and Markku Heli{\"o}vaara and Samuli Ripatti and Anneli Pouta and {\AA}sa Torinsson Naluai and Anna-Carin Olin and Kjell Tor{\'e}n and Matthew N Cooper and Alan L. James and Lyle J Palmer and Aroon D. Hingorani and S Goya Wannamethee and Peter Whincup and George Davey Smith and Shah Ebrahim and Tricia M McKeever and Ian D. Pavord and Andrew K MacLeod and Andrew D. Morris and David J. Porteous and Cyrus Cooper and Elaine Dennison and Seif Shaheen and S Karrasch and Eva Schnabel and Holger Schulz and Harald Grallert and Nabila Bouatia-Naji and J{\'e}r{\^o}me Delplanque and Philippe Froguel and John D Blakey and John R Britton and Richard W Morris and John W Holloway and Debbie A Lawlor and Jennie Hui and Fredrik Nyberg and Marjo-Riitta Jarvelin and Cathy Jackson and Mika K{\"a}h{\"o}nen and Jaakko Kaprio and Nicole Probst-Hensch and Beate Koch and Caroline Hayward and David M Evans and Paul Elliott and David P Strachan and Ian P Hall and Martin D Tobin},
  journal={Nature Genetics},
  year={2010},
  volume={42},
  pages={36-44}
}
Pulmonary function measures are heritable traits that predict morbidity and mortality and define chronic obstructive pulmonary disease (COPD). We tested genome-wide association with forced expiratory volume in 1 s (FEV1) and the ratio of FEV1 to forced vital capacity (FVC) in the SpiroMeta consortium (n = 20,288 individuals of European ancestry). We conducted a meta-analysis of top signals with data from direct genotyping (n ≤ 32,184 additional individuals) and in silico summary association… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 190 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 41 references

A genome-wide association study of pulmonary function measures in the Framingham Heart Study

  • Wilk, J.B
  • PLoS Genet. 5,
  • 2009

Gene expression profiles of acute exacerbations of Idiopathic Pulmonary Fibrosis

  • K Konishi
  • Am. J. Respir. Crit. Care Med
  • 2009

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function

  • Hancock, D.B
  • Nat. Genet. advance online publication,
  • 2009

an analysis of the framingham offspring cohort

  • Kohansal, R. et al. The natural history of chronic airflow obst revisited
  • Am. J. Respir. Crit. Care Med. 180, 3–10
  • 2009

identification of two major susceptibility loci

  • Pillai, S. G. et al. A genome-wide association study in chron COPD
  • PLoS Genet. 5, e1000421
  • 2009

the core pathway and its posttranslational regulation

  • Fortini, M. E. Notch signaling
  • Dev. Cell 16, 633–647
  • 2009

A role for the receptor for advanced glycation end products in idiopathic pulmonary fibrosis

  • Englert, J.M
  • Am. J. Pathol
  • 2008

Similar Papers

Loading similar papers…