Genome-wide association study identifies five loci associated with lung function

  title={Genome-wide association study identifies five loci associated with lung function},
  author={Emmanouela Repapi and Ian Sayers and Louise V Wain and Paul R. Burton and Toby Johnson and Ma'en Obeidat and Jing Hua Zhao and Adaikalavan Ramasamy and Guangju Zhai and Veronique Vitart and Jennifer E Huffman and Wilmar Igl and Eva Albrecht and Panos Deloukas and John Henderson and R. Granell and Wendy L. Mcardle and Alicja R. Rudnicka and In{\^e}s Barroso and Ruth J. F. Loos and Nicholas J Wareham and L Mustelin and Taina Rantanen and Ida Surakka and Medea Imboden and H. Erich Wichmann and Ivica Grkovi{\'c} and Stipan Jankovi{\'c} and Lina Zgaga and A Hartikainen and Leena Peltonen and Ulf Gyllensten and {\AA}sa Johansson and Ghazal Zaboli and Harry Campbell and Sarah H Wild and James F Wilson and Sven Gl{\"a}ser and Georg Homuth and Henry V{\"o}lzke and Massimo Mangino and Nicole Soranzo and Tim D. Spector and Ozren Pola{\vs}ek and Igor Rudan and Alan F. Wright and Markku Heli{\"o}vaara and Samuli Ripatti and Anneli Pouta and {\AA}sa Torinsson Naluai and A Olin and Kjell Tor{\'e}n and Matthew N Cooper and Alan L. James and Lyle John Palmer and Aroon D. Hingorani and Sasiwarang Goya Wannamethee and Peter Whincup and George Davey Smith and Shah Ebrahim and Tricia M McKeever and Ian D. Pavord and Andrew K MacLeod and Andrew D. Morris and David J. Porteous and Cyrus Cooper and Elaine Dennison and Seif Shaheen and S Karrasch and Eva Schnabel and Holger Schulz and Harald Grallert and Nabila Bouatia-Naji and J{\'e}r{\^o}me Delplanque and Philippe Froguel and John D. Blakey and J Robert Britton and Richard W. Morris and John W Holloway and Debbie A Lawlor and Jennie Hui and Fredrik Nyberg and Marjo-Riitta Jarvelin and Cathy Jackson and Mika K{\"a}h{\"o}nen and Jaakko Kaprio and Nicole Probst-Hensch and Beate Koch and Caroline Hayward and David M. Evans and Paul Elliott and David P. Strachan and Ian P Hall and Martin D Tobin},
  journal={Nature Genetics},
Pulmonary function measures are heritable traits that predict morbidity and mortality and define chronic obstructive pulmonary disease (COPD). We tested genome-wide association with forced expiratory volume in 1 s (FEV1) and the ratio of FEV1 to forced vital capacity (FVC) in the SpiroMeta consortium (n = 20,288 individuals of European ancestry). We conducted a meta-analysis of top signals with data from direct genotyping (n ≤ 32,184 additional individuals) and in silico summary association… CONTINUE READING
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