Genome-wide association study identifies ephrin type A receptors implicated in paclitaxel induced peripheral sensory neuropathy.

@article{LeandroGarca2013GenomewideAS,
  title={Genome-wide association study identifies ephrin type A receptors implicated in paclitaxel induced peripheral sensory neuropathy.},
  author={Luis Javier Leandro-Garc{\'i}a and Luc{\'i}a Inglada-P{\'e}rez and Guillermo Pita and Elisabet Hjerpe and Susanna Leskel{\"a} and C Jara and Xabier Mielgo and Anna Gonz{\'a}lez-Neira and Mercedes Robledo and Elisabeth {\AA}vall-Lundqvist and Henrik Gr{\'e}en and Cristina Rodr{\'i}guez-Antona},
  journal={Journal of medical genetics},
  year={2013},
  volume={50 9},
  pages={599-605}
}
BACKGROUND Peripheral neuropathy is the dose limiting toxicity of paclitaxel, a chemotherapeutic drug widely used to treat solid tumours. This toxicity exhibits great inter-individual variability of unknown origin. The present study aimed to identify genetic variants associated with paclitaxel induced neuropathy via a whole genome approach. METHODS A genome-wide association study (GWAS) was performed in 144 white European patients uniformly treated with paclitaxel/carboplatin and for whom… CONTINUE READING
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