Genome-wide association study identifies eight loci associated with blood pressure

  title={Genome-wide association study identifies eight loci associated with blood pressure},
  author={Christopher Newton-Cheh and Toby Johnson and Vesela Gateva and Martin D. Tobin and Murielle Bochud and Lachlan J. Coin and Samer S. Najjar and Jing Hua Zhao and Simon C. Heath and Susana Eyheramendy and Konstantinos Papadakis and Benjamin F. Voight and Laura J. Scott and Feng Zhang and Martin Farrall and Toshiko Tanaka and Chris Wallace and John C Chambers and Kay-Tee Khaw and Peter M. Nilsson and Pim van der Harst and Silvia Polidoro and Diederick E. Grobbee and N. Charlotte Onland-Moret and Michiel L. Bots and Louise V. Wain and Katherine S. Elliott and Alexander Teumer and Jian’an Luan and Gavin J A Lucas and Johanna Kuusisto and Paul R. Burton and David Hadley and Wendy L McArdle and Morris J. Brown and Anna F. Dominiczak and Stephen J. Newhouse and Nilesh J. Samani and John Webster and Eleftheria Zeggini and Jacques S. Beckmann and S. Bergmann and Noha Lim and Kijoung Song and Peter Vollenweider and G{\'e}rard Waeber and Dawn M. Waterworth and Xin Yuan and Leif C. Groop and Marju Orho-Melander and Alessandra Allione and Alessandra Di Gregorio and Simonetta Guarrera and Salvatore Panico and Fulvio Ricceri and Valeria Romanazzi and Carlotta Sacerdote and Paolo Vineis and In{\^e}s Barroso and Manjinder S. Sandhu and Robert N. Luben and Gabriel J Crawford and Pekka Jousilahti and Markus Perola and Michael Boehnke and Lori L Bonnycastle and Francis S. Collins and Anne U. Jackson and Karen L. Mohlke and Heather M. Stringham and Timo T. Valle and Cristen J. Willer and Richard N. Bergman and Mario A. Morken and Angela D{\"o}ring and Christian Gieger and Thomas Illig and Thomas Meitinger and Elin Org and Arne Pfeufer and Heinz-Erich Wichmann and Sekar Kathiresan and Jaume Marrugat and Christopher J. O’Donnell and Stephen M. Schwartz and David S. Siscovick and Isaac Subirana and Nelson B. Freimer and A-L. Hartikainen and Mark I. McCarthy and Paul F. O’Reilly and Leena Peltonen and Anneli Pouta and Paul E. de Jong and Harold Snieder and Wiek H. van Gilst and Robert J. Clarke and Anuj Goel and Anders Hamsten and John F. Peden and Udo Seedorf and Ann-Christine Syv{\"a}nen and Giovanni Tognoni and Edward G. Lakatta and Serena Sanna and Paul Scheet and David Schlessinger and Angelo Scuteri and Marcus D{\"o}rr and Florian D. Ernst and Stephan B. Felix and Georg Homuth and Roberto Lorbeer and Thorsten Reffelmann and Rainer Rettig and Uwe V{\"o}lker and Pilar Galan and Ivo Glynne Gut and Serge Hercberg and G. Mark Lathrop and Diana Z{\'e}l{\'e}nika and Panos Deloukas and Nicole Soranzo and Frances M. K. Williams and Guangju Zhai and Veikko V Salomaa and Markku Laakso and Roberto Elos{\'u}a and Nita G. Forouhi and Henry V{\"o}lzke and Cuno S.P.M. Uiterwaal and Yvonne T. Schouw and Mattijs Everard Numans and Giuseppe Matullo and Gerjan J Navis and Göran Berglund and Sheila Anne Bingham and Jaspal S Kooner and John M. Connell and Stefania Bandinelli and Luigi Ferrucci and Hugh C. Watkins and Tim D. Spector and Jaakko Tuomilehto and David M Altshuler and David P. Strachan and Maris Laan and Pierre Meneton and Nicholas J. Wareham and Manuela Uda and Marjo-Riitta Jarvelin and Vincent Mooser and Olle Melander and Ruth J. F. Loos and Paul Elliott and Gonçalo R. Abecasis and Mark J. Caulfield and Patricia B. Munroe},
  journal={Nature Genetics},
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N ≤ 71,225 European ancestry, N ≤ 12,889 Indian Asian ancestry) and in silico… 

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