Genome-wide association study identifies eight loci associated with blood pressure

@article{NewtonCheh2009GenomewideAS,
  title={Genome-wide association study identifies eight loci associated with blood pressure},
  author={Christopher Newton-Cheh and Toby Johnson and Vesela Gateva and Martin D. Tobin and Murielle Bochud and Lachlan J Coin and Samer S. Najjar and Jing Hua Zhao and Simon C. Heath and Susana Eyheramendy and Konstantinos Papadakis and Benjamin F. Voight and Laura J. Scott and Feng Zhang and Martin Farrall and Toshiko Tanaka and Chris Wallace and John Campbell Chambers and Kay-Tee Khaw and Peter M. Nilsson and Pim van der Harst and Silvia Polidoro and Diederick E. Grobbee and N. Charlotte Onland-Moret and Michiel L. Bots and Louise V. Wain and Katherine S. Elliott and Alexander Teumer and Jian’an Luan and Gavin J A Lucas and Johanna Kuusisto and Paul R. Burton and David Hadley and Wendy L McArdle and Morris J. Brown and Anna F. Dominiczak and Stephen Newhouse and Nilesh J. Samani and John Webster and Eleftheria Zeggini and Jacques S. Beckmann and Sven Bergmann and Noha Lim and Kijoung Song and Peter Vollenweider and G{\'e}rard Waeber and Dawn Waterworth and Xin Yuan and Leif C Groop and Marju Orho-Melander and Alessandra Allione and Alessandra Di Gregorio and Simonetta Guarrera and Salvatore Panico and Fulvio Ricceri and Valeria Romanazzi and Carlotta Sacerdote and Paolo Vineis and In{\^e}s Barroso and Manjinder S. Sandhu and Robert N. Luben and Gabriel J Crawford and Pekka Jousilahti and Markus Perola and Michael Boehnke and Lori L Bonnycastle and Francis S. Collins and Anne U. Jackson and Karen L. Mohlke and Heather M. Stringham and Timo T. Valle and Cristen J. Willer and Richard N. Bergman and Mario A. Morken and Angela D{\"o}ring and Christian Gieger and Thomas Illig and Thomas Heinz Meitinger and Elin Org and Arne Pfeufer and Heinz-Erich Wichmann and Sekar Kathiresan and Jaume Marrugat and Christopher J. O’Donnell and Stephen M. Schwartz and David S Siscovick and Isaac Subirana and Nelson B. Freimer and A-L. Hartikainen and Mark I. McCarthy and Paul F. O’Reilly and Leena Peltonen and Anneli Pouta and Paul E. de Jong and Harold Snieder and Wiek H. van Gilst and Robert J. Clarke and Anuj Goel and Anders Hamsten and John F. Peden and Udo Seedorf and Ann-Christine Syv{\"a}nen and Giovanni Tognoni and Edward G. Lakatta and Serena Sanna and Paul Scheet and David Schlessinger and Angelo Scuteri and Marcus D{\"o}rr and Florian D. Ernst and Stephan B. Felix and Georg Homuth and Roberto Lorbeer and Thorsten Reffelmann and Rainer Rettig and Uwe V{\"o}lker and Pilar Galan and Ivo Glynne Gut and Serge Hercberg and G. M. Lathrop and Diana Z{\'e}l{\'e}nika and Panos Deloukas and Nicole Soranzo and Frances M. K. Williams and Guangju Zhai and Veikko V Salomaa and Markku Laakso and Roberto Elosua and Nita G. Forouhi and Henry V{\"o}lzke and Cuno S.P.M. Uiterwaal and Yvonne T. Schouw and Mattijs E. Numans and Giuseppe Matullo and Gerjan J Navis and Göran Berglund and Sheila Anne Bingham and Jaspal S Kooner and John M. Connell and Stefania Bandinelli and Luigi Ferrucci and Hugh C. Watkins and Tim D. Spector and Jaakko Tuomilehto and David M Altshuler and David P. Strachan and Maris Laan and Pierre Meneton and Nicholas J. Wareham and Manuela Uda and Marjo-Riitta Jarvelin and Vincent Mooser and Olle Melander and Ruth J. F. Loos and Paul Elliott and Gonçalo R. Abecasis and Mark J. Caulfield and Patricia B. Munroe},
  journal={Nature Genetics},
  year={2009},
  volume={41},
  pages={666-676}
}
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N ≤ 71,225 European ancestry, N ≤ 12,889 Indian Asian ancestry) and in silico… Expand
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High blood pressure (BP) is a major risk factor for cardiovascular disease (CVD) and is more prevalent in African Americans as compared to other US groups. Although large, population-basedExpand
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References

SHOWING 1-10 OF 111 REFERENCES
Genome-wide association study of blood pressure and hypertension
TLDR
A genome-wide association study of systolic (SBP) and diastolic (DBP) blood pressure and hypertension in the CHARGE Consortium identifies 13 SNPs for SBP, 20 for DBP and 10 for hypertension at P < 4 × 10−7. Expand
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
TLDR
The results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D, and detect at least six previously unknown loci with robust evidence for association. Expand
Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure
TLDR
Common genetic variants at the NPPA-NPPB locus found to be associated with circulating natriuretic peptide concentrations contribute to interindividual variation in blood pressure and hypertension. Expand
A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants
TLDR
The number of T2D loci now confidently identified to at least 10 is confirmed, and it is confirmed that variants near TCF7L2, SLC30A8, HHEX, FTO, PPARG, and KCNJ11 are associated with T1D risk. Expand
Common Variants in Genes Underlying Monogenic Hypertension and Hypotension and Blood Pressure in the General Population
TLDR
It is shown that common variants in genes responsible for some Mendelian disorders of hypertension and hypotension affect blood pressure in the general population, and variants in KCNJ1, which causes Bartter syndrome type 2, were strongly associated, potentially providing a novel target for intervention. Expand
Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels
TLDR
The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases. Expand
Common variants near MC4R are associated with fat mass, weight and risk of obesity
TLDR
It is established that common variants near MC4R influence fat mass, weight and obesity risk at the population level and reinforce the need for large-scale data integration to identify variants influencing continuous biomedical traits. Expand
Genome-wide mapping of human loci for essential hypertension
TLDR
The results of a genome scan for hypertension in a large white European population imply that human essential hypertension has an oligogenic element (a few genes may be involved in determination of the trait) possibly superimposed on more minor genetic effects, and that several genes might be tractable to a positional cloning strategy. Expand
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
TLDR
This study increases the number of T1D loci with compelling evidence from six to at least ten, with evidence for chromosome 18q22 and 18p11, which showed association with autoimmune thyroid disease. Expand
Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p.
TLDR
A simultaneous test of CAD and diabetes susceptibility with CAD and T2D-associated SNPs indicated that these associations were independent of each other. Expand
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