Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

@inproceedings{Deelen2011GenomewideAS,
  title={Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited},
  author={Joris Deelen and Marian Beekman and Hae-Won Uh and Quinta Helmer and Maris Kuningas and Lene Christiansen and Dennis Kremer and Ruud van der Breggen and H Eka D Suchiman and N. Lakenberg and Erik B. van den Akker and Willemijn M. Passtoors and Henning Tiemeier and Diana van Heemst and Anton J. M. de Craen and Fernando Rivadeneira and Eco J. C. de Geus and Markus Perola and Frans J G van der Ouderaa and David Gunn and Dorret I. Boomsma and Andr{\'e} G. Uitterlinden and Kaare Christensen and Cornelia M van Duijn and Bastiaan T Heijmans and Jeanine J. Houwing-Duistermaat and Rudi G J Westendorp and Pieternella E Slagboom},
  booktitle={Aging cell},
  year={2011}
}
By studying the loci that contribute to human longevity, we aim to identify mechanisms that contribute to healthy aging. To identify such loci, we performed a genome-wide association study (GWAS) comparing 403 unrelated nonagenarians from long-living families included in the Leiden Longevity Study (LLS) and 1670 younger population controls. The strongest candidate SNPs from this GWAS have been analyzed in a meta-analysis of nonagenarian cases from the Rotterdam Study, Leiden 85-plus study, and… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 73 references

The genetics of ageing

Nature • 2010
View 4 Excerpts
Highly Influenced

Association of FOXO3A variation with human longevity confirmed in German centenarians.

Proceedings of the National Academy of Sciences of the United States of America • 2009
View 8 Excerpts
Highly Influenced

FOXO3A genotype is strongly associated with human longevity.

Proceedings of the National Academy of Sciences of the United States of America • 2008
View 8 Excerpts
Highly Influenced

Inheritance of human longevity in Iceland

H Gudmundsson, DF Gudbjartsson, M Frigge, JR Gulcher, K Stefansson
Eur. J. Hum. Genet • 2000
View 2 Excerpts
Highly Influenced

A meta - analysis of four genome - wide association studies of survival to age 90 years or older : the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium

H Nybo, HC Petersen, +4 authors K Christensen
J . Gerontol . A Biol . Sci . Med . Sci . • 2010

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