Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2

@article{Yue2011GenomewideAS,
  title={Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2},
  author={Wei-hua Yue and Hai-feng Wang and Liangdan Sun and Fu-Lei Tang and Zhonghua Liu and Hong-Xing Zhang and Wen-qiang Li and Yanling Zhang and Yang Zhang and Cui-Cui Ma and Bo Du and Li-Fang Wang and Yun-qing Ren and Yong-feng Yang and Xiao-Feng Hu and Yi Wang and Wei Wu Deng and Li-wen Tan and Yun-long Tan and Qi Chen and Guang-Ming Xu and Gui-Gang Yang and Xian-bo Zuo and Hao Yan and Yan-yan Ruan and Tian-Lan Lu and Xue Han and Xiao-Hong Ma and Yan Wang and Li-Wei Cai and Chao Jin and Hong-yan Zhang and Jun Yan and Wei-Feng Mi and Xian-yong Yin and Wenli Ma and Qi Liu and Lan Lan Kang and Wei Sun and Cheng-Ying Pan and Mei Shuang and Fu-de Yang and Chuan-yue Wang and Jian-li Yang and Kun-peng Li and Xin Ma and Lingjiang Li and Xin Yu and Qinghang Li and Xun Wilson Huang and Lu-xian Lv and Tao Li and Guo-Ping Zhao and Wei Huang and Xuejun Zhang and Hongxing Zhang},
  journal={Nature Genetics},
  year={2011},
  volume={43},
  pages={1228-1231}
}
To identify susceptibility loci for schizophrenia, we performed a two-stage genome-wide association study (GWAS) of schizophrenia in the Han Chinese population (GWAS: 746 individuals with schizophrenia and 1,599 healthy controls; validation: 4,027 individuals with schizophrenia and 5,603 healthy controls). We identified two susceptibility loci for schizophrenia at 6p21-p22.1 (rs1233710 in an intron of ZKSCAN4, Pcombined = 4.76 × 10−11, odds ratio (OR) = 0.79; rs1635 in an exon of NKAPL… CONTINUE READING
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