Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behçet's disease
@article{Lee2013GenomewideAS, title={Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behçet's disease}, author={Y. Lee and Yukihiro Horie and G. Wallace and Yong Seok Choi and Ji Ah Park and Ji Yong Choi and Ran Song and Y. Kang and S. Kang and Han Joo Baek and N. Kitaichi and A. Meguro and N. Mizuki and K. Namba and S. Ishida and Jinhyun Kim and E. Niemczyk and Eun Young Lee and Yeong Wook Song and S. Ohno and E. Lee}, journal={Annals of the Rheumatic Diseases}, year={2013}, volume={72}, pages={1510 - 1516} }
Objectives To identify non-major histocompatibility complex susceptible genes that might contribute to Behçet's disease (BD). Methods We performed a genome-wide association study using DNA samples from a Korean population consisting of 379 BD patients and 800 controls. A replication study was performed in a Japanese population (363 BD patients and 272 controls). To evaluate the functional implication of the target single nucleotide polymorphisms (SNP), gene expression levels in peripheral T… CONTINUE READING
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References
SHOWING 1-10 OF 51 REFERENCES
Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci
- Biology, Medicine
- Nature Genetics
- 2010
- 424
Identification of novel genetic susceptibility loci for Behçet's disease using a genome-wide association study
- Biology, Medicine
- Arthritis research & therapy
- 2009
- 112
Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R/IL12RB2 regions associated with Behçet's disease
- Biology, Medicine
- Nature Genetics
- 2010
- 486
The human GIMAP5 gene has a common polyadenylation polymorphism increasing risk to systemic lupus erythematosus
- Biology, Medicine
- Journal of Medical Genetics
- 2007
- 64
HLA-B51/B5 and the risk of Behçet's disease: a systematic review and meta-analysis of case-control genetic association studies.
- Medicine
- Arthritis and rheumatism
- 2009
- 289
IA-2 autoantibodies in incident type I diabetes patients are associated with a polyadenylation signal polymorphism in GIMAP5
- Biology, Medicine
- Genes and Immunity
- 2007
- 43
- PDF
TNF polymorphisms in patients with Behçet disease: a meta-analysis.
- Medicine
- Archives of medical research
- 2010
- 56
- PDF
Behçet's disease: an update on the pathogenesis.
- Medicine
- Clinical and experimental rheumatology
- 2001
- 256
T-bet expression is upregulated in active Behçet’s disease
- Medicine
- The British journal of ophthalmology
- 2003
- 47
- PDF