Genome-wide association study identifies 74 loci associated with educational attainment

  title={Genome-wide association study identifies 74 loci associated with educational attainment},
  author={Aysu Okbay and Jonathan P. Beauchamp and Mark A. Fontana and James J Lee and Tune H. Pers and Cornelius A. Rietveld and Patrick Turley and Guo-Bo Chen and Valur Emilsson and S. Fleur W. Meddens and Sven Oskarsson and Joseph K. Pickrell and Kevin Thom and Pascal Timshel and Ronald de Vlaming and Abdel Abdellaoui and Tarunveer S Ahluwalia and Jonas Bacelis and Clemens Baumbach and Gyda Bjornsdottir and Johannes H. Brandsma and Maria Pina Concas and Jaime Derringer and Nicholas A. Furlotte and Tessel E. Galesloot and Giorgia Girotto and Richa Gupta and L. M. Hall and Sarah E Harris and E Hofer and Momoko Horikoshi and Jennifer E Huffman and Kadri Kaasik and Ioanna Panagiota Kalafati and Robert Karlsson and Augustine Kong and Jari Lahti and Sven J van der Lee and Christiaan de Leeuw and Penelope A Lind and Karl-Oskar Lindgren and Tian Liu and Massimo Mangino and Jonathan Marten and Evelin Mihailov and Michael B. Miller and Peter J van der Most and Christopher Oldmeadow and A. M. Payton and Natalia Pervjakova and Wouter J. Peyrot and Yong Qian and Olli T. Raitakari and Rico Rueedi and Erika Salvi and Boerge Schmidt and Katharina E. Schraut and Jianxin Shi and Albert Vernon Smith and Raymond A. Poot and Beate St. Pourcain and Alexander Teumer and Gudmar Thorleifsson and Niek Verweij and Dragana Vuckovic and Jürgen Wellmann and Harm-Jan Westra and Jingyun Yang and Wei Zhao and Zhihong Zhu and Behrooz Z. Alizadeh and Najaf Amin and Andrew Bakshi and Sebastian E. Baumeister and Ginevra Biino and Klaus B{\o}nnelykke and Patricia A. Boyle and Harry Campbell and Francesco P Cappuccio and Gail Davies and Jan-Emmanuel De Neve and Panos Deloukas and Ilja Demuth and Jun Ding and Peter Eibich and Lewin Eisele and Niina Eklund and David M. Evans68 and Jessica D. Faul and Mary F Feitosa and Andreas J Forstner and Ilaria Gandin and Bjarni Gunnarsson and Bjarni V Halldorsson and T. B. Harris and Andrew Craig Heath and Lynne J. Hocking and Elizabeth G. Holliday and Georg Homuth and Michael A. Horan and Jouke-Jan Hottenga and Philip L De Jager and Peter K Joshi and Astanand Jugessur and Marika A. Kaakinen and Mika K{\"a}h{\"o}nen and Stavroula Kanoni and Liisa Keltigangas-J{\"a}rvinen and Lambertus A Kiemeney and Ivana Kol{\vc}i{\'c} and Seppo Koskinen and Aldi Kraja and Martin Kroh and Zolt{\'a}n Kutalik and Antti Latvala and Lenore J. Launer and Ma{\"e}l P. Lebreton and Douglas F. Levinson and Paul Lichtenstein and Peter Lichtner and David C M Liewald and Anu Loukola and Pamela A. F. Madden and Reedik M{\"a}gi and Tomi E. M{\"a}ki-Opas and Riccardo E. Marioni and Pedro Manuel Marques-Vidal and Gerardus A. Meddens and George Mcmahon and Christa Meisinger and Thomas Meitinger and Yusplitri Milaneschi and Lili Milani and Grant W. Montgomery and Ronny Myhre and Christopher Patrick Nelson and Dale R. Nyholt and William E. R. Ollier and Aarno Palotie and Lavinia Paternoster and Carsten B{\o}cker Pedersen and Katja Petrovic and David J. Porteous and Katri R{\"a}ikk{\"o}nen and Susan M Ring and Antonietta Robino and Olga Rostapshova and Igor Rudan and Aldo Rustichini and Veikko V Salomaa and Alan R. Sanders and Antti-Pekka Sarin and Helena Schmidt and Rodney J. Scott and Blair H Smith and Jennifer A. Smith and Jan A. Staessen and Elisabeth Steinhagen-Thiessen and Konstantin Strauch and A. Terracciano and Martin D Tobin and Sheila Ulivi and Simona Vaccargiu and Lydia Quaye and Frank J. A. van Rooij and Cristina Venturini and Anna A. E. Vinkhuyzen and Uwe V{\"o}lker and Henry V{\"o}lzke and Judith M Vonk and Diego Vozzi and Johannes Waage and Erin B Ware and Gonneke H. M. Willemsen and John R Attia and David A. Bennett and Klaus Berger and Lars Bertram and Hans Bisgaard and Dorret I. Boomsma and Ingrid B. Borecki and Ute Bultmann and Christopher F. Chabris and Francesco Cucca and Daniele Cusi and Ian J Deary and George Vassilios Dedoussis and Cornelia M van Duijn and Johan G Eriksson and Barbara Franke and Lude Franke and Paolo Gasparini and Pablo V. Gejman and Christian Gieger and Hans- J{\"o}rgen Grabe and Jacob Gratten and Patrick J. F. Groenen and Vilmundur Gudnason and Pim van der Harst and Caroline Hayward and David A. Hinds and Wolfgang Hoffmann and Elina Hypp{\"o}nen and William G. Iacono and Bo Jacobsson and Marjo-Riitta J{\"a}rvelin and Karl-Heinz J{\"o}ckel and Jaakko Kaprio and Sharon L. R. Kardia and Terho Lehtim{\"a}ki and Steven F. Lehrer and Patrik K E Magnusson and Nicholas G. Martin and M K Mcgue and Andres Metspalu and Neil Pendleton and Brenda W. J. H. Penninx and Markus Perola and Nicola Pirastu and Mario Pirastu and Ozren Pola{\vs}ek and Danielle Posthuma and Christine Power and Michael A. Province and Nilesh J. Samani and David Schlessinger and Reinhold Schmidt and Thorkild I A S{\o}rensen and Tim D. Spector and K{\'a}ri Stef{\'a}nsson and Unnur Thorsteinsdottir and A Roy Thurik and Nicholas J. Timpson and Henning Tiemeier and Joyce Y. Tung and Andr{\'e} G. Uitterlinden and Veronique Vitart and Peter Vollenweider and David R. Weir and James F Wilson and Alan Wright and Dalton C. Conley and Robert F Krueger and George Davey Smith and Albert Hofman and David Laibson and Sarah E. Medland and Michelle N. Meyer and Jian Yang and Magnus Johannesson and Peter M. Visscher and T{\~o}nu Esko and Philipp D Koellinger and David Cesarini and Daniel J Benjamin},
Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals. Here we report the results of a genome-wide association study (GWAS) for educational attainment that extends our earlier discovery sample of 101,069 individuals to 293,723 individuals, and a replication study in an independent sample of 111,349 individuals from the UK Biobank. We identify 74 genome-wide… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.

267 Citations

Citations per Year
Semantic Scholar estimates that this publication has 267 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.

An atlas of genetic correlations across human diseases and traits

  • B Bulik-Sullivan
  • Nat Genet
  • 2015

Replicability and robustness of GWAS for behavioral traits

  • CA Rietveld
  • Psychol Sci
  • 2014

Similar Papers

Loading similar papers…