Genome-wide association study identifies 30 Loci Associated with Bipolar Disorder

@article{Stahli2017GenomewideAS,
  title={Genome-wide association study identifies 30 Loci Associated with Bipolar Disorder},
  author={Eli A Stahli and A. Forstner and A. McQuillin and S. Ripke and V. Trubetskoy and M. Mattheisen and W. Wang and Yunpeng Wang and J. Coleman and H. Gaspar and C. D. de Leeuw and Jennifer M Whitehead Pavlides and L. O. Olde Loohuis and A. Ori and T. H. Pers and P. Holmans and D. Ruderfer and P. Lee and A. Charney and A. Dobbyn and L. Huckins and J. Boocock and C. Giambartolomei and P. Roussos and N. Mullins and S. Awasthi and E. Agerbo and T. Als and C. Pedersen and J. Grove and R. Kupka and E. Regeer and A. Anjorin and M. Casas and C. S{\'a}nchez-Mora and Pamela B. Mahon and S. Purcell and S. McCarroll and J. Allardyce and V. Escott-Price and L. Forty and C. Fraser and M. Hamshere and G. Kirov and M. Kogevinas and J. Frank and F. Streit and J. Strohmaier and J. Treutlein and S. Witt and J. Kennedy and J. Strauss and J. Garnham and C. O'donovan and C. Slaney and S. Steinberg and T. Thorgeirsson and M. Hautzinger and M. Steffens and R. Perlis and M. Hipolito and W. Lawson and E. Nwulia and S. Levy and T. Foroud and S. Jamain and A. Young and J. McKay and D. Albani and P. Zandi and J. Potash and Peng Zhang and J. Depaulo and Sarah L Bergen and A. Jur{\'e}us and R. Karlsson and R. Kandaswamy and P. McGuffin and M. Rivera and J. Lissowska and C. Cruceanu and S. Lucae and P. Cervantes and M. Budde and K. Gade and U. Heilbronner and M. Pedersen and D. Morris and C. Weickert and T. Weickert and D. Macintyre and J. Lawrence and T. Elvs{\aa}shagen and O. Smeland and S. Djurovic and Simon Xi and E. Green and P. Czerski and J. Hauser and W. Xu and H. Vedder and L. Oru{\vc} and A. T. Spijker and S. Gordon and S. Medland and D. Curtis and Thomas W M{\"u}hleisen and J. Badner and William A. Scheftner and E. Sigurdsson and N. Schork and A. Schatzberg and M. B{\ae}kvad-Hansen and J. Bybjerg-Grauholm and Christine S{\o}holm Hansen and J. Knowles and H. Medeiros and S. Szelinger and G. Montgomery and M. Boks and A. Adolfsson and N. Bass and P. Hoffmann and M. Bauer and A. Pfennig and M. Leber and S. Kittel-Schneider and A. Reif and J. Del-Favero and S. Fischer and S. Herms and C. Reinbold and F. Degenhardt and Anna C. Koller and A. Maaser and W. Maier and N. Freimer and A. Dale and C. Fan and T. Greenwood and C. Nievergelt and Tatyana Shehktman and Paul D. Shilling and W. Byerley and W. Bunney and N. Alliey-Rodriguez and D. Blackwood and T. Clarke and C. Liu and W. Coryell and H. Akil and M. Burmeister and M. Flickinger and J. Li and M. McInnis and F. Meng and R. Thompson and S. Watson and Sebastian K. Zollner and W. Guan and M. Green and D. Craig and J. Sobell and L. Milani and K. Gordon-Smith and S. Knott and A. Perry and J. Guzman Parra and F. Mayoral and F. Rivas and J. Rice and J. Barchas and A. B{\o}rglum and P. Mortensen and O. Mors and M. Grigoroiu-Serbanescu and F. Bellivier and B. {\'E}tain and M. Leboyer and J. Ramos-Quiroga and M. Ribas{\'e}s and T. Esko and J. Smoller and N. Craddock and I. Jones and M. Owen and M. Rietschel and T. Schulze and J. Vincent and E. Vieta and M. Nordentoft and M. Alda and H. Stef{\'a}nsson and K. Stef{\'a}nsson and D. Posthuma and I. Agartz and K. Oedegaard and E. Stordal and R. Myers and R. Kahn and T. Werge and Q. Li and F. Goes and C. Hultman and M. Land{\'e}n and P. Sullivan and C. Lewis and S. McElroy and B. M{\"u}ller-Myhsok and J. Biernacka and M. Frye and G. Turecki and G. Rouleau and F. McMahon and J. Fullerton and P. Schofield and G. Morken and U. Malt and I. Melle and S. Paciga and N. Martin and A. Vaaler and D. Hougaard and C. Pato and M. Pato and A. Corvin and M. Gill and R. Adolfsson and B. Baune and A. Serretti and M. N{\"o}then and E. Gershon and A. McIntosh and M. Boehnke and U. Dannlowski and P. Mitchell and W. Berrettini and V. Nimgaonkar and A. Metspalu and L. Jones and J. Nurnberger and N. Wray and A. Florio and M. O’Donovan and H. Edenberg and R. Ophoff and L. Scott and S. Cichon and O. Andreassen and P. Sklar and J. Kelsoe and G. Breen},
  journal={bioRxiv},
  year={2017}
}
Bipolar disorder is a highly heritable psychiatric disorder that features episodes of mania and depression. We performed the largest genome-wide association study to date, including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 881 sentinel variants at loci with P<1×10-4 in an independent sample of 9,412 cases and 137,760 controls. In the combined analysis, 30 loci achieved genome-wide significance including 18 novel loci. These significant loci contain genes… Expand
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