Genome-wide association study and meta-analysis finds over 40 loci affect risk of type 1 diabetes

  title={Genome-wide association study and meta-analysis finds over 40 loci affect risk of type 1 diabetes},
  author={Jeffrey C. Barrett and David G. Clayton and Patrick Concannon and Beena Akolkar and Jason. D Cooper and Henry A. Erlich and C{\'e}cile Julier and Grant Morahan and J\orn Nerup and Concepcion R. Nierras and Vincent Plagnol and Flemming Pociot and Helen Schuilenburg and Deborah J. Smyth and Helen E. Stevens and John A. Todd and Neil M. Walker and Stephen S. Rich},
  booktitle={Nature Genetics},
Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously published studies. The total sample set included 7,514 cases and 9,045 reference samples. Forty-one distinct genomic locations provided evidence for association with T1D in the meta-analysis (P < 10−6). After excluding previously reported associations… CONTINUE READING
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