Genome-wide association studies of adolescent idiopathic scoliosis suggest candidate susceptibility genes.

  title={Genome-wide association studies of adolescent idiopathic scoliosis suggest candidate susceptibility genes.},
  author={Swarkar Sharma and Xiaochong Gao and Douglas Londono and Shonn E Devroy and Kristen N Mauldin and Jessica T Frankel and January M Brandon and Dongping Zhang and Quan-Zhen Li and Matthew B. Dobbs and Christina A. Gurnett and Struan F. A. Grant and Hakon Hakonarson and John Paul Dormans and John Herring and Derek Gordon and Carol A. Wise},
  journal={Human molecular genetics},
  volume={20 7},
Adolescent idiopathic scoliosis (AIS) is an unexplained and common spinal deformity seen in otherwise healthy children. Its pathophysiology is poorly understood despite intensive investigation. Although genetic underpinnings are clear, replicated susceptibility loci that could provide insight into etiology have not been forthcoming. To address these issues, we performed genome-wide association studies (GWAS) of ∼327 000 single nucleotide polymorphisms (SNPs) in 419 AIS families. We found… CONTINUE READING


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