Genome-wide association studies in Alzheimer disease.

  title={Genome-wide association studies in Alzheimer disease.},
  author={Stephen C. Waring and Roger N. Rosenberg},
  journal={Archives of neurology},
  volume={65 3},
The genetics of Alzheimer disease (AD) to date support an age-dependent dichotomous model whereby earlier age of disease onset (< 60 years) is explained by 3 fully penetrant genes (APP [NCBI Entrez gene 351], PSEN1 [NCBI Entrez gene 5663], and PSEN2 [NCBI Entrez gene 5664]), whereas later age of disease onset (> or = 65 years) representing most cases of AD has yet to be explained by a purely genetic model. The APOE gene (NCBI Entrez gene 348) is the strongest genetic risk factor for later onset… CONTINUE READING