Genome-wide association studies identify four ER negative–specific breast cancer risk loci

  title={Genome-wide association studies identify four ER negative–specific breast cancer risk loci},
  author={Montserrat Garc{\'i}a-Closas and Fergus J. Couch and Sara Lindstrom and Kyriaki Michailidou and Marjanka K. Schmidt and Mark N Brook and Nick Orr and Suhn Kyong Rhie and Elio Riboli and Heather Spencer Feigelson and Loic Le Marchand and Julie E. Buring and Diana Eccles and Penelope L. Miron and Peter A. Fasching and Hiltrud Brauch and Jenny Chang-Claude and Jane E. Carpenter and Andrew K. Godwin and Heli Nevanlinna and Graham G. Giles and Angela Cox and John L. Hopper and Manjeet K. Bolla and Qin Wang and Joe Dennis and Ed Dicks and Will J Howat and Nils Schoof and Stig Egil Bojesen and Diether Lambrechts and Annegien Broeks and Irene L Andrulis and Pascal Gu{\'e}nel and Barbara Burwinkel and Elinor J. Sawyer and Antoinette Hollestelle and Olivia Fletcher and Robert Winqvist and Hermann Brenner and Arto J Mannermaa and Ute Hamann and Alfons Meindl and A. Arto Lindblom and Wei Zheng and Peter Devillee and Mark S. Goldberg and Jan A. Lubiński and Vessela N. Kristensen and Anthony J Swerdlow and Hoda Anton-Culver and Thilo D{\"o}rk and Kenneth Ross Muir and Keitaro Matsuo and Anna H Wu and Paolo Radice and Soo Hwang Teo and Xiao-ou Shu and William J. Blot and Daehee Kang and M. Hartman and Suleeporn Sangrajrang and Chen-yang Shen and Melissa C. Southey and Daniel J. Park and Fleur Hammet and Jennifer Stone and Laura J. van't Veer and Emiel J. Th Rutgers and Artitaya Lophatananon and Sarah Lynette Stewart-Brown and Pornthep Siriwanarangsan and Julian Peto and Michael G. Schrauder and Arif B. Ekici and Matthias W. Beckmann and Isabel M dos Santos Silva and Nichola Johnson and H Jane Warren and Ian Tomlinson and Michael John Kerin and Nicola M Miller and Federick Marme and Andreas Schneeweiss and Christof Sohn and Th{\'e}r{\`e}se Truong and Pierre Laurent-Puig and Pierre Kerbrat and B\orge G. Nordestgaard and Sune Fallgaard Nielsen and Henrik Flyger and Roger L Milne and Jos{\'e} Ignacio Arias P{\'e}rez and Primitiva Men{\'e}ndez and Heiko Mueller and Volker Arndt and Christa Stegmaier and Peter Lichtner and Magdalena Lochmann and Christina Justenhoven and Y D Ko and Taru A Muranen and Kristiina Aittom{\"a}ki and Carl Blomqvist and Dario Greco and Tuomas Heikkinen and Hidemi Ito and Hiroji Iwata and Yasushi Yatabe and Natalia N. Antonenkova and Sara Margolin and Vesa V. Kataja and Veli-Matti Kosma and Jaana M. Hartikainen and Rosemary L. Balleine and Chiu-chen Tseng and David J. Van Den Berg and Daniel O. Stram and Patrick Neven and A. S. Dieudonn{\'e} and Karin Leunen and Anja Rudolph and Stefan Nickels and Dieter Flesch-Janys and Paolo Peterlongo and Bernard Peissel and Loris Bernard and Janet E. Olson and Xianshu Wang and Kristen Stevens and Gianluca Severi and Laura Baglietto and Catriona A. McLean and Gerhard A. Coetzee and Ye Feng and Brian E. Henderson and Fredrick Schumacher and Natalia Valerijevna Bogdanova and France Labr{\`e}che and Martine Dumont and Cheng-Har Yip and Nur Aishah Mohd Taib and Ching-Yu Cheng and Martha J Shrubsole and Jirong Long and Katri Pylk{\"a}s and Arja Jukkola-Vuorinen and Saila Kauppila and J. A. G. Knight and Gordon Glendon and Anna Marie Mulligan and Robertus Alexandre Eduard Mattheus Tollenaar and Caroline M. Seynaeve and Mieke G. Kriege and Maartje J. Hooning and Ans M. W. van den Ouweland and Carolien H. M. van Deurzen and Wei Lu and Yu-tang Gao and Hui Cai and Sabapathy Prakash Balasubramanian and Simon S. Cross and Malcolm W. R. Reed and Lisa B. Signorello and Qiuyin Cai and Mitul H. Shah and Hui Miao and Ching Chan and Kee Seng Chia and Anna Jakubowska and Katarzyna Jaworska and Katarzyna Durda and C Hsiung and P Wu and Jyh-Cherng Yu and Alan Ashworth and Michael Jones and Daniel C. Tessier and Anna Gonz{\'a}lez-Neira and Guillermo Pita and Maria Del Rosario Zariategui de Alonso and Daniel D Vincent and François Bacot and Christine B. Ambrosone and Elisa V. Bandera and Esther M John and Gary K. Chen and Jennifer Hu and Jorge L. Rodriguez-Gil and Leslie Bernstein and Michael F Press and Regina G Ziegler and Robert M Millikan and Sandra L Deming-Halverson and Sarah J. Nyante and Sue Ann Ingles and Quinten Waisfisz and Helen Tsimiklis and Enes Makalic and Daniel F. Schmidt and Minh Bui and Lorna Gibson and Bertram M{\"u}ller-Myhsok and Rita Katharina Schmutzler and Rebecca Hein and Norbert Dahmen and Lars Beckmann and Kirsimari Aaltonen and Kamila Czene and Astrid Irwanto and Jianping Liu and C. R. A. Turnbull and Nazneen Rahman and Hanne Meijers-Heijboer and Andr{\'e} G. Uitterlinden and Fernando Rivadeneira and Curtis L Olswold and Susan L. Slager and Robert T. Pilarski and Foluso Ademuyiwa and Irene Konstantopoulou and Nicholas G. Martin and Grant W. Montgomery and Dennis J. Slamon and Claudia Rauh and Michael P Lux and Sebastian M Jud and Thomas Bruning and Joellen Weaver and Priyanka Sharma and Harsh mohan Pathak and Will J Tapper and Sue M Gerty and Lorraine T Durcan and Dimitirios Trichopoulos and Rosario Tumino and Petra H. M. Peeters and Rudolf Kaaks and Daniele Campa and Frederico Canzian and Elisabete Weiderpass and Mattias Johansson and Kay-tee Khaw and Rowland Travis and Francoise Clavel-Chapelon and Laurence N. Kolonel and Constance M. Chen and Andy H. Beck and Susan E. Hankinson and C. T. van den Berg and Robert Nathaniel Hoover and Jolanta Lissowska and Jonine D Figueroa and Daniel Chasman and Mia M Gaudet and W Ryan Diver and Walter C Willett and David J. Hunter and Jacques Simard and Javier Ben{\'i}tez and Alison M. Dunning and Mark E. Sherman and Georgia Chenevix-Trench and Stephen J. Chanock and Per Hall and Paul D. P. Pharoah and Celine M. Vachon and Douglas F. Easton and Christopher A. Haiman and Peter Kraft},
  journal={Nature Genetics},
Estrogen receptor (ER)-negative tumors represent 20–30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition. To identify susceptibility loci specific to ER-negative disease, we combined in a meta-analysis 3 genome-wide association studies of 4,193 ER-negative breast cancer… CONTINUE READING
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