Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci

@article{Mizuki2010GenomewideAS,
  title={Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci},
  author={Nobuhisa Mizuki and Akira Meguro and Masao Ota and Shigeaki Ohno and Tomoko Shiota and Tatsukata Kawagoe and Norihiko Ito and Jiro Kera and Eiichi Okada and Keisuke Yatsu and Yeong Wook Song and Eun-Bong Lee and Nobuyoshi Kitaichi and Kenichi Namba and Yukihiro Horie and Mitsuhiro Takeno and Sunao Sugita and Manabu Mochizuki and Seiamak Bahram and Yoshiaki I Ishigatsubo and Hidetoshi Inoko},
  journal={Nature Genetics},
  year={2010},
  volume={42},
  pages={703-706}
}
Behçet's disease is a chronic systemic inflammatory disorder characterized by four major manifestations: recurrent ocular symptoms, oral and genital ulcers and skin lesions. We conducted a genome-wide association study in a Japanese cohort including 612 individuals with Behçet's disease and 740 unaffected individuals (controls). We identified two suggestive associations on chromosomes 1p31.3 (IL23R-IL12RB2, rs12119179, P = 2.7 × 10−8) and 1q32.1 (IL10, rs1554286, P = 8.0 × 10−8). A meta… CONTINUE READING
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