Genome-wide association studies for common diseases and complex traits

  title={Genome-wide association studies for common diseases and complex traits},
  author={J. Hirschhorn and M. Daly},
  journal={Nature Reviews Genetics},
  • J. Hirschhorn, M. Daly
  • Published 2005
  • Biology, Medicine
  • Nature Reviews Genetics
  • Genetic factors strongly affect susceptibility to common diseases and also influence disease-related quantitative traits. Identifying the relevant genes has been difficult, in part because each causal gene only makes a small contribution to overall heritability. Genetic association studies offer a potentially powerful approach for mapping causal genes with modest effects, but are limited because only a small number of genes can be studied at a time. Genome-wide association studies will soon… CONTINUE READING

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