Genome-wide association studies for common diseases and complex traits

@article{Hirschhorn2005GenomewideAS,
  title={Genome-wide association studies for common diseases and complex traits},
  author={Joel N. Hirschhorn and Mark J. Daly},
  journal={Nature Reviews Genetics},
  year={2005},
  volume={6},
  pages={95-108}
}
Genetic factors strongly affect susceptibility to common diseases and also influence disease-related quantitative traits. Identifying the relevant genes has been difficult, in part because each causal gene only makes a small contribution to overall heritability. Genetic association studies offer a potentially powerful approach for mapping causal genes with modest effects, but are limited because only a small number of genes can be studied at a time. Genome-wide association studies will soon… 
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