Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21

@article{Tenesa2008GenomewideAS,
  title={Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21},
  author={A. Tenesa and S. Farrington and J. Prendergast and M. Porteous and M. Walker and N. Haq and R. Barnetson and E. Theodoratou and R. Cetnarskyj and Nicola Cartwright and C. Semple and Andrew J Clark and Fiona J L Reid and L. A. Smith and K. Kavoussanakis and T. Koessler and P. Pharoah and S. Buch and C. Schafmayer and J. Tepel and S. Schreiber and H. V{\"o}lzke and C. Schmidt and J. Hampe and J. Chang-Claude and M. Hoffmeister and H. Brenner and S. Wilkening and F. Canzian and G. Capell{\'a} and V. Moreno and I. Deary and J. Starr and I. Tomlinson and Zoe Kemp and Kimberley Howarth and L. Carvajal-Carmona and E. Webb and P. Broderick and J. Vijayakrishnan and R. Houlston and G. Rennert and D. Ballinger and L. Rozek and S. Gruber and K. Matsuda and T. Kidokoro and Y. Nakamura and B. Zanke and C. Greenwood and J. Rangrej and R. Kustra and A. Montpetit and T. Hudson and S. Gallinger and H. Campbell and M. Dunlop},
  journal={Nature Genetics},
  year={2008},
  volume={40},
  pages={631-637}
}
In a genome-wide association study to identify loci associated with colorectal cancer (CRC) risk, we genotyped 555,510 SNPs in 1,012 early-onset Scottish CRC cases and 1,012 controls (phase 1). In phase 2, we genotyped the 15,008 highest-ranked SNPs in 2,057 Scottish cases and 2,111 controls. We then genotyped the five highest-ranked SNPs from the joint phase 1 and 2 analysis in 14,500 cases and 13,294 controls from seven populations, and identified a previously unreported association… Expand
595 Citations
GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12
  • 26
  • PDF
Fine-mapping of genome-wide association study-identified risk loci for colorectal cancer in African Americans.
  • 29
  • PDF
A genome-wide association study for colorectal cancer identifies a risk locus in 14q23.1
  • 25
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 24 REFERENCES
Germline susceptibility to colorectal cancer due to base-excision repair gene defects.
  • 280
  • PDF
Association of MUTYH and colorectal cancer
  • 100
  • PDF
A common genetic risk factor for colorectal and prostate cancer
  • 372
  • PDF
Validity of tagging SNPs across populations for association studies
  • 19
  • PDF
...
1
2
3
...