Genome-wide association replicates the association of Duffy antigen receptor for chemokines (DARC) polymorphisms with serum monocyte chemoattractant protein-1 (MCP-1) levels in Hispanic children.

@article{Voruganti2012GenomewideAR,
  title={Genome-wide association replicates the association of Duffy antigen receptor for chemokines (DARC) polymorphisms with serum monocyte chemoattractant protein-1 (MCP-1) levels in Hispanic children.},
  author={Venkata Saroja Voruganti and Sandra L. Laston and Karin Haack and Nitesh R. Mehta and Conrad W. Smith and S. A. Cole and Nancy F Butte and Anthony Gean Comuzzie},
  journal={Cytokine},
  year={2012},
  volume={60 3},
  pages={634-8}
}
Obesity is associated with a chronic low inflammatory state characterized by elevated levels of chemokines. Monocyte chemoattractant protein-1 (MCP-1) is a member of the cysteine-cysteine (CC) chemokine family and is increased in obesity. The purpose of this study was to identify loci regulating serum MCP-1 in obese Hispanic children from the Viva La Familia Study. A genome-wide association (GWA) analysis was performed in 815 children, ages 4-19 years, using genotypes assayed with the Illumina… CONTINUE READING