Genome-wide association of copy-number variation reveals an association between short stature and the presence of low-frequency genomic deletions.

@article{Dauber2011GenomewideAO,
  title={Genome-wide association of copy-number variation reveals an association between short stature and the presence of low-frequency genomic deletions.},
  author={Andrew Dauber and Yongguo Yu and Michael C. Turchin and Charleston W K Chiang and Yan A. Meng and Ellen W. Demerath and Sanjay R. Patel and Stephen S. Rich and Jerome I. Rotter and Pamela J. Schreiner and James G. Wilson and Yiping Shen and Bai-Lin Wu and Joel Hirschhorn},
  journal={American journal of human genetics},
  year={2011},
  volume={89 6},
  pages={
          751-9
        }
}
Height is a model polygenic trait that is highly heritable. Genome-wide association studies have identified hundreds of single-nucleotide polymorphisms associated with stature, but the role of structural variation in determining height is largely unknown. We performed a genome-wide association study of copy-number variation and stature in a clinical cohort of children who had undergone comparative genomic hybridization (CGH) microarray analysis for clinical indications. We found that subjects… CONTINUE READING
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