Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C

@article{Tanaka2009GenomewideAO,
  title={Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C},
  author={Yasuhito Tanaka and Nao Nishida and M Sugiyama and Masayuki Kurosaki and Kentaro Matsuura and Naoya Sakamoto and Mina Nakagawa and Masaaki Korenaga and Keisuke Hino and Shuhei Hige and Yoshito Ito and Eiji Mita and Eiji Tanaka and Satoshi Mochida and Yoshikazu Murawaki and Masao Honda and Akito Sakai and Yoichi Hiasa and Shuhei Nishiguchi and Asako Koike and Isao Sakaida and Masatoshi Imamura and Kiyoaki Ito and Koji Yano and Naohiko Masaki and Fuminaka Sugauchi and Namiki Izumi and Katsushi Tokunaga and Masashi Mizokami},
  journal={Nature Genetics},
  year={2009},
  volume={41},
  pages={1105-1109}
}
The recommended treatment for patients with chronic hepatitis C, pegylated interferon-α (PEG-IFN-α) plus ribavirin (RBV), does not provide sustained virologic response (SVR) in all patients. We report a genome-wide association study (GWAS) to null virological response (NVR) in the treatment of patients with hepatitis C virus (HCV) genotype 1 within a Japanese population. We found two SNPs near the gene IL28B on chromosome 19 to be strongly associated with NVR (rs12980275, P = 1.93 × 10−13, and… CONTINUE READING
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