Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus

@article{Morris2016GenomewideAM,
  title={Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus},
  author={David Lester Morris and Yujun Sheng and Yan Zhang and Yong-Fei Wang and Zhengwei Zhu and Philip Tombleson and Lingyan Chen and Deborah S. Cunninghame Graham and James Bentham and Amy L. Roberts and Ruoyan Chen and Xianbo Zuo and Tingyou Wang and Leilei Wen and Chao Yang and Lu Liu and Lulu Yang and Feng Li and Yuanbo Huang and Xianyong Yin and Sen Yang and Lars R{\"o}nnblom and Barbara G F{\"u}rnrohr and Reinhard Edmund Voll and Georg Schett and Nathalie Costedoat–Chalumeau and Patrick M Gaffney and Yu Lung Lau and Xuejun Zhang and Wanling Yang and Yong Cui and Timothy J Vyse},
  journal={Nature Genetics},
  year={2016},
  volume={48},
  pages={940-946}
}
Systemic lupus erythematosus (SLE; OMIM 152700) is a genetically complex autoimmune disease. Genome-wide association studies (GWASs) have identified more than 50 loci as robustly associated with the disease in single ancestries, but genome-wide transancestral studies have not been conducted. We combined three GWAS data sets from Chinese (1,659 cases and 3,398 controls) and European (4,036 cases and 6,959 controls) populations. A meta-analysis of these studies showed that over half of the… CONTINUE READING
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Characterization of human disease phenotypes associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1

  • Crow, Y.J
  • Am. J. Med. Genet. A. 167,
  • 2015

A general approach for haplotype phasing across the full spectrum of relatedness

  • J O’Connell
  • PLoS Genet. 10,
  • 2014

Identification of novel genetic loci associated with thyroid peroxidase antibodies and clinical thyroid disease

  • M Medici
  • PLoS Genet. 10,
  • 2014

Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes

  • T Raj
  • Science 344,
  • 2014

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