Genome-wide association interaction analysis for Alzheimer's disease

  title={Genome-wide association interaction analysis for Alzheimer's disease},
  author={Elena S. Gusareva and Minerva M. Carrasquillo and C{\'e}line Bellenguez and Elise Cuyvers and Samuel Colon and Neill R. Graff-Radford and Ronald C. Petersen and Dennis W. Dickson and Jestinah M. Mahachie John and Kyrylo Bessonov and Christine Van Broeckhoven and Denise Harold and Julie Williams and Philippe Amouyel and Kristel Sleegers and Nil{\"u}fer Ertekin-Taner and J Y Lambert and Kristel Van Steen},
  journal={Neurobiology of Aging},
We propose a minimal protocol for exhaustive genome-wide association interaction analysis that involves screening for epistasis over large-scale genomic data combining strengths of different methods and statistical tools. The different steps of this protocol are illustrated on a real-life data application for Alzheimer's disease (AD) (2259 patients and 6017 controls from France). Particularly, in the exhaustive genome-wide epistasis screening we identified AD-associated interacting SNPs-pair… CONTINUE READING
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Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications

  • N. R. Graff-Radford, D. W. Dickson, S. G. Younkin, N. Ertekin-Taner
  • Mol. Neurodegener
  • 2012

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